Recombinant Human Soluble RANK Ligand | MyBioSource MBS142211 product information

product summary

request information :

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Soluble RANK Ligand

catalog :

MBS142211

quantity :

0.01 mg

price :

205 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142211

products type :

Recombinant Protein

products full name :

Recombinant Human Soluble RANK Ligand

products short name :

Soluble RANK Ligand

products name syn :

sRANKL Human; RANK Ligand Soluble Human Recombinant; Soluble Receptor Activator of NFkB Ligand; TNFSF11; TRANCE; TNF-related activation-induced cytokine; OPGL; ODF; Osteoclast differentiation factor; Tumor necrosis factor ligand superfamily member 11; Receptor activator of nuclear factor kappa B ligand; RANKL; Osteoprotegerin ligand; CD254 antigen; sRANKL; sOdf; hRANKL2

other names :

tumor necrosis factor ligand superfamily member 11 isoform 1; Tumor necrosis factor ligand superfamily member 11; tumor necrosis factor ligand superfamily member 11; TNF-related activation-induced cytokine; osteoclast differentiation factor; osteoprotegerin ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor (ligand) superfamily, member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD_antigen: CD254Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form

products gene name :

sRANKL

other gene names :

TNFSF11; TNFSF11; ODF; OPGL; sOdf; CD254; OPTB2; RANKL; TRANCE; hRANKL2; OPGL; RANKL; TRANCE; ODF; OPGL; RANKL; TRANCE

uniprot entry name :

TNF11_HUMAN

host :

E Coli

sequence length :

317

sequence :

MEKAMVDGSW LDLAKRSKLE AQPFAHLTIN ATDIPSGSHK VSLSSWYHDR GWAKISNMTF SNGKLIVNQD GFYYLYANIC FRHHETSGDL ATEYLQLMVY VTKTSIKIPS SHTLMKGGST KYWSGNSEFH FYSINVGGFF KLRSGEEISI EVSNPSLLDP DQDATYFGAF KVRDID.

purity :

Greater than 90.0% as determined by analysis by SDS-PAGE.

form :

The protein was lyophilized from a concentrated (1mg/ml) solution containing 10mM Na2PO4, pH-8.0. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized TNFSF11 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution sRANKL should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized sRANKL in sterile 18M Omega -cm H2O at a concentration of 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The activity is determined by a dose-dependent stimulation of IL-8 production in human PBMC and is typically less than 100ng/ml, corresponding to a specific activity of 10,000 Units/mg.

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors; RANK Ligand

products description :

Description: sRANKL Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 176 amino acids and having a molecular mass of 20 kDa. Introduction: RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

ncbi gi num :

4507595

ncbi acc num :

NP_003692.1

ncbi gb acc num :

NM_003701.3

uniprot acc num :

O14788

ncbi mol weight :

30,523 Da

ncbi pathways :

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!IL6-mediated Signaling Events Pathway 137932!!NF-kappa B Signaling Pathway 634527!!Osteoblast Signaling Pathway 198842!!Osteoclast Signaling Pathway 198769!!Osteoclast Differentiation Pathway 193147!!Osteoclast Differentiation Pathway 193096!!Prolactin Signaling Pathway 814182!!Prolactin Signaling Pathway 814248

ncbi summary :

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]

size :

0.01 mg

price :

205 USD

more info or order :

MyBioSource product webpage