catalog number :
MBS142210
products type :
Recombinant Protein
products full name :
Recombinant Human Bone Morphogenetic protein-7
products short name :
Morphogenetic protein-7
products name syn :
BMP 7 Human; Bone Morphogenetic Protein-7 Human Recombinant; Osteogenic Protein 1; BMP-7
other names :
bone morphogenetic protein 7; Bone morphogenetic protein 7; bone morphogenetic protein 7; osteogenic protein 1; bone morphogenetic protein 7; Osteogenic protein 1; OP-1; INN: Eptotermin alfa
products gene name :
BMP 7
other gene names :
BMP7; BMP7; OP-1; OP1; BMP-7; OP-1
uniprot entry name :
BMP7_HUMAN
sequence :
The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Thr-Gly-Ser-Lys.
purity :
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
BMP-7 was lyophilized from a concentrated (1mg/ml) sterile solution containing 10mM sodium citrate pH=3.5. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized BMP-7 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution BMP 7 Human should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
other info2 :
Solubility: It is recommended to briefly centrifuge the vial prior to opening to bring the contents to the bottom. Reconstitute in 20mM-100mM acetic acid at a concentration of 0.1-0.5mg per ml. Stock solutions should be apportioned into working aliquots and stored at <-20 degree C. Further dilutions should be made in appropriate buffered solutions.
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; Bone Morphogenetic Protein
products description :
Description: Bone Morphogenetic Protein-7 Human Recombinant produced in E Coli is a monomeric, non-glycosylated, polypeptide chain containing 139 amino acids and having a molecular mass of 15679.97 Dalton. The BMP-7 is purified by proprietary chromatographic techniques. Introduction: The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has lead to speculation of possible bone inductive activity.
ncbi acc num :
NP_001710.1
ncbi gb acc num :
NM_001719.2
ncbi mol weight :
49,313 Da
ncbi pathways :
ALK2 Signaling Events Pathway 137983!!BMP Receptor Signaling Pathway 137948!!BMP Signaling Pathway 1084755!!BMP Signaling Pathway 1108218!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Elastic Fibre Formation Pathway 730310!!Endochondral Ossification Pathway 198812!!Extracellular Matrix Organization Pathway 576262!!Hippo Signaling Pathway 749777
ncbi summary :
The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development and possible bone inductive activity. [provided by RefSeq, Jul 2008]