protein

Recombinant Human Interleukin-22

MBS142205

0.002 mg

140 USD

Recombinant Protein

Recombinant Human Interleukin-22

Interleukin-22

IL 22 Human; Interleukin-22 Human Recombinant; IL-TIF; TIFa; IL-10-related T-cell-derived-inducible factor; IL-22; ILTIF; IL-D110; zcyto18; MGC79382; MGC79384; TIFIL-23

interleukin-22; Interleukin-22; interleukin-22; IL-10-related T-cell-derived inducible factor; IL-10-related T-cell-derived-inducible factor; cytokine Zcyto18; interleukin 22; Cytokine Zcyto18; IL-10-related T-cell-derived-inducible factor; IL-TIF

IL 22

IL22; IL22; TIFa; IL-21; IL-22; ILTIF; IL-TIF; IL-D110; zcyto18; TIFIL-23; ILTIF; ZCYTO18; IL-22; IL-TIF

IL22_HUMAN

E Coli

179

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Pro-Ile-Ser.

Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Each mg contains 50mM Phosphate buffer pH=7.1. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized Interleukin-22 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL22 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized Interleukin -22 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The Biological Activity was determined by the ability to activiate STAT following receptor ligand interaction.

CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin

Description: Interleukin-22 Human Recombinant produced in E Coli is a single, non-glycosylated homodimeric polypeptide chain containing 2 x 146 amino acids and having a total molecular mass of 33,607 Dalton. The IL-22 is purified by proprietary chromatographic techniques. Introduction: IL-22 is a member of the IL-10 family of regulatory cytokines.Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-beta/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.

10092625

NP_065386.1

NM_020525.4

Q9GZX6

20,011 Da

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Inflammatory Bowel Disease (IBD) Pathway (842771); Inflammatory Bowel Disease (IBD) Pathway (842797); Jak-STAT Signaling Pathway (83077); Jak-STAT Signaling Pathway (488)

IL22: Cytokine that contributes to the inflammatory response in vivo. Belongs to the IL-10 family. Protein type: Cytokine; Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 12q15. Cellular Component: extracellular space; extracellular region. Molecular Function: interleukin-22 receptor binding; cytokine activity. Biological Process: cell-cell signaling; response to glucocorticoid stimulus; acute-phase response; inflammatory response

0.002 mg

140 USD

0.01 mg

205

1 mg

4550