protein

Recombinant Mouse Soluble RANK Ligand

MBS142197

0.01 mg

205 USD

Recombinant Protein

Recombinant Mouse Soluble RANK Ligand

Soluble RANK Ligand

sRANKL Mouse; RANK Ligand Soluble Mouse Recombinant; Soluble Receptor Activator of NFkB Ligand; TNFSF11; TRANCE; TNF-related activation-induced cytokine; OPGL; ODF; Osteoclast differentiation factor; Tumor necrosis factor ligand superfamily member 11; Receptor activator of nuclear factor kappa B ligand; RANKL; Osteoprotegerin ligand; CD254 antigen; sRANKL; sOdf

tumor necrosis factor ligand superfamily member 11; Tumor necrosis factor ligand superfamily member 11; tumor necrosis factor ligand superfamily member 11; OPG ligand; TNF-related activation-induced cytokine; osteoclast differentiation factor; osteoprotegerin ligand; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa B ligand; receptor activator of nuclear factor kappa-B ligand; tumor necrosis factor-related activation-induced cytokine; tumor necrosis factor (ligand) superfamily, member 11; Osteoclast differentiation factor; ODF; Osteoprotegerin ligand; OPGL; Receptor activator of nuclear factor kappa-B ligand; RANKL; TNF-related activation-induced cytokine; TRANCE; CD_antigen: CD254Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 11, membrane form; Tumor necrosis factor ligand superfamily member 11, soluble form

msRANKL

Tnfsf11; Tnfsf11; ODF; OPG; OPGL; RANKL; Ly109l; Trance; Opgl; Rankl; Trance; ODF; OPGL; RANKL; TRANCE

TNF11_MOUSE

E Coli

316

PAMMEGSWLD VAQRGKPEAQ PFAHLTINAA SIPSGSHKVT LSSWYHDRGW AKISNMTLSN GKLRVNQDGF YYLYANICFR HHETSGSVPT DYLQLMVYVV KTSIKIPSSH NLMKGGSTKN WSGNSEFHFY SINVGGFFKL RAGEEISIQV SNPSLLDPDQ DATYFGAFKV QDID.

Greater than 95.0% as determined by SDS-PAGE.

The protein (1mg/ml) was lyophilized with 10mM Na2PO4, pH 7.5 & 50mM NaCl. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized TNFSF11 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution sRANKL should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized sRANKL in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: Measured by its ability to induce osteoclast formation on murine RAW264.7 cells using a concentration of 50ng/ml shown in œCorning Osteo Assay Surface 24 Well Plates with Transwell Permeable Supports- A Useful Tool for Co-Culture Studies by Rebecca M. Wood and Mark Rothenber, corresponding to a specific activity of 20,000Units/mg.

CYTOKINES AND GROWTH FACTORS; Growth Factors; RANK Ligand

Description: sRANKL Mouse Recombinant produced in E Coli is single, non-glycosylated, polypeptide chain containing 174 amino acids and having a total molecular mass of 19.9kDa.CD254 is purified by proprietary chromatographic techniques. Introduction: RANKL binds to tnfrsf11b/opg and to tnfrsf11a/rank. Osteoclast differentiation and activation factor. augments the ability of dendritic cells to stimulate naive t-cell proliferation. May be an important regulator of interactions between t-cells and dendritic cells and may play a role in the regulation of the t-cell-dependent immune response. sRANKL may also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

114842415

NP_035743.2

NM_011613.3

O35235

22,150 Da

Cytokine-cytokine Receptor Interaction Pathway 83248!!Cytokine-cytokine Receptor Interaction Pathway 460!!NF-kappa B Signaling Pathway 634537!!Osteoblast Pathway 198413!!Osteoclast Pathway 198284!!Osteoclast Differentiation Pathway 193149!!Osteoclast Differentiation Pathway 193096!!Prolactin Signaling Pathway 814197!!Prolactin Signaling Pathway 814248!!Rheumatoid Arthritis Pathway 200310

0.01 mg

205 USD