Recombinant Human Transforming Growth Factor-Beta 3 (644-850) | MyBioSource MBS142196 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Transforming Growth Factor-Beta 3 (644-850)

catalog :

MBS142196

quantity :

0.002 mg

price :

265 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142196

products type :

Recombinant Protein

products full name :

Recombinant Human Transforming Growth Factor-Beta 3 (644-850)

products short name :

Transforming Growth Factor-Beta 3

products name syn :

TGF b 3 (207 a.a.) Human; Transforming Growth Factor-Beta 3 (207 a.a.) Human Recombinant; Transforming Growth Factor-beta3; TGFB3; ARVD; FLJ16571; TGF-beta3; TGF b 3 (207 a.a.)

other names :

transforming growth factor beta-3 preproprotein; Transforming growth factor beta-3; transforming growth factor beta-3; TGF-beta-3; prepro-transforming growth factor beta-3; transforming growth factor, beta 3

products gene name :

TGF b 3

other gene names :

TGFB3; TGFB3; ARVD; RNHF; ARVD1; TGF-beta3; TGF-beta-3; LAP

uniprot entry name :

TGFB3_HUMAN

host :

E Coli

sequence length :

412

form :

100 ul purified human TGF Beta 3protein at 100 ug/ml in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol. Sterile Filtered clear solution.

storage stability :

TGF-beta 3 Human Recombinant although stable at 4 degree C for 1 week, should be stored at -20 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze-thaw cycles.

tested application :

ELISA (EIA), Inhibition Assays, Western Blot (WB)

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors; Transforming Growth Factor

products description :

Description: TGFB3 Human Recombinant protein encoding amino acids 644-850 and total molecular mass of 50 kDa (Including GST Tag). Introduction: Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGF Betas have been identified in mammals. TGF Beta 1, TGF Beta 2 and TGF Beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule.

ncbi gi num :

4507465

ncbi acc num :

NP_003230.1

ncbi gb acc num :

NM_003239.3

uniprot acc num :

P10600

ncbi mol weight :

35,708 Da

ncbi pathways :

ALK1 Signaling Events Pathway (137968); Amoebiasis Pathway (167324); Amoebiasis Pathway (167191); Cell Cycle Pathway (83054); Cell Cycle Pathway (463); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Chronic Myeloid Leukemia Pathway (83116); Chronic Myeloid Leukemia Pathway (528); Colorectal Cancer Pathway (83106)

ncbi summary :

This gene encodes a member of the TGF-beta family of proteins. The encoded protein is secreted and is involved in embryogenesis and cell differentiation. Defects in this gene are a cause of familial arrhythmogenic right ventricular dysplasia 1. [provided by RefSeq, Mar 2009]

uniprot summary :

TGFB3: Involved in embryogenesis and cell differentiation. Homodimer; disulfide-linked. Interacts with ASPN. Belongs to the TGF-beta family. Protein type: Ligand, receptor tyrosine kinase; Secreted, signal peptide; Cell development/differentiation; Secreted; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 14q24. Cellular Component: extracellular matrix; extracellular space; cell surface; cell soma; T-tubule; plasma membrane; extracellular region; nucleus. Molecular Function: identical protein binding; protein binding; growth factor activity; protein heterodimerization activity; transforming growth factor beta binding; punt binding; cytokine activity. Biological Process: extracellular matrix organization and biogenesis; activation of MAPK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; positive regulation of collagen biosynthetic process; SMAD protein nuclear translocation; female pregnancy; palate development; regulation of apoptosis; odontogenesis; negative regulation of cell proliferation; platelet degranulation; mammary gland development; transforming growth factor beta receptor signaling pathway; salivary gland morphogenesis; embryonic neurocranium morphogenesis; negative regulation of neuron apoptosis; cell growth; inner ear development; aging; positive regulation of filopodium formation; uterine wall breakdown; intercellular junction assembly and maintenance; platelet activation; in utero embryonic development; positive regulation of bone mineralization; regulation of cell proliferation; gut development; positive regulation of protein secretion; response to estrogen stimulus; negative regulation of DNA replication; regulation of MAPKKK cascade; positive regulation of cell division; response to hypoxia; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transforming growth factor beta receptor signaling pathway; blood coagulation; response to progesterone stimulus; alveolus development; positive regulation of DNA replication. Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 1; Rienhoff Syndrome

size1 :

0.002 mg

price1 :

265 USD

size2 :

0.005 mg

price2 :

365

size3 :

0.01 mg

price3 :

620

more info or order :

MyBioSource product webpage