protein

Recombinant Human AITRL, His Tag

MBS142194

0.02 mg

205 USD

Recombinant Protein

Recombinant Human AITRL, His Tag

AITRL

AITRL Human, His; AITRL Human Recombinant, His Tag; Osteostat; TNFSF18; Activation-induced TNFR member Ligand; GITRL; TL6; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL; Tumor necrosis factor ligand superfamily member 18; MGC138237; AITRL His

tumor necrosis factor ligand superfamily member 18; Tumor necrosis factor ligand superfamily member 18; tumor necrosis factor ligand superfamily member 18; AITR ligand; GITR ligand; activation-inducible TNF-related ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand; tumor necrosis factor (ligand) superfamily, member 18; Activation-inducible TNF-related ligand; AITRL; Glucocorticoid-induced TNF-related ligand; hGITRL

AITRL

TNFSF18; TNFSF18; TL6; AITRL; GITRL; hGITRL; AITRL; GITRL; TL6; AITRL; hGITRL

TNF18_HUMAN

E Coli

199

MRGSHHHHHH GMASTAKEPC MAKFGPLPSK WQMASSEPPC VNKVSDWKLE ILQNGLYLIY GQVAPNANYNDVAPFEVRLY KNKDMIQTLT NKSKIQNVGG TYELHVGDTI DLIFNSEHQV LKNNTYWGII LLANPQFIS.

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Lyophilized from 0.5 mg/ml in 0.03M Acetate buffer, pH-4. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized AITRL although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution AITRL should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Solubility: Add 0.2 ml of 0.1M Acetate buffer pH-4 and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10 ug/ml. In higher concentrations the solubility of this antigen is limited.

CYTOKINES AND GROWTH FACTORS; Cytokines; AITRL

Description: The Human AITRL His-Tagged Recombinant Protein, produced in E Coli, is 15.7 kDa (calculated) protein containing 125 amino acid residues of the human AITRL and 14 additional amino acid residues - HisTag (underlined). The amino acid sequence of the recombinant human Osteostat is homologous to the extracellular domain of the human TNF18, Thr53-Ser177. Introduction: Osteostat is the cytokine that binds to TNFRSF18/AITR/GITR and is important for interactions between activated T-lymphocytes and endothelial cells and may modulate T-lymphocyte survival in peripheral tissues. Osteostat is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells after stimulation by lipopolysaccharides.Osteostat protein is detectable in human microvascular EC and is highly up-regulated by IFN-alpha and IFN-beta. Osteostat inhibit differentiation of osteoclasts from monocytic precursor cells. Osteostat suppresses the early stage of osteoclastogenesis via inhibition of macrophage colony-stimulating factorinduced receptor activator of NF-kappaB (RANK) expression in the osteoclast precursor cells. Osteostat does not inhibit lipopolysaccharide-induced RANK expression in monocytes and dendritic cells, or activation-induced RANK expression in T cells. Osteostat is a novel regulator of osteoclast generation and substantiate the major role played by the endothelium in bone physiology.

157419142

NP_005083.2

NM_005092.3

Q9UNG2

22,724 Da

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008]

0.02 mg

205 USD