protein

Recombinant Mouse RELM-alpha

MBS142186

0.005 mg

140 USD

Recombinant Protein

Recombinant Mouse RELM-alpha

RELM-alpha

RELM a Mouse; RELM-alpha Mouse Recombinant; Resistin-like alpha; RELMalpha; Cysteine-rich secreted protein FIZZ1; Parasite-induced macrophage novel gene 1 protein; Cysteine-rich secreted protein A12-gamma; RELM-a

resistin-like alpha; Resistin-like alpha; resistin-like alpha; cysteine-rich secreted protein A12-gamma; cysteine-rich secreted protein FIZZ1; found in inflammatory zone 1; hypoxia-induced mitogenic factor; parasite-induced macrophage novel gene 1 protein; resistin like alpha; Cysteine-rich secreted protein A12-gamma; Cysteine-rich secreted protein FIZZ1; Hypoxia-induced mitogenic factor; Parasite-induced macrophage novel gene 1 protein; RELMalpha

mRELM a

Retnla; Retnla; HIMF; Xcp2; Fizz1; RELMa; Fizz-1; RELMalpha; RELM-alpha; 1810019L16Rik; Fizz1; Himf; Pmng1

RETNA_MOUSE

E Coli

138

MDETIEIIVE NKVKELLANP ANYPSTVTKT LSCTSVKTMN RWASCPAGMT ATGCACGFAC GSWEIQSGDT CNCLCLLVDW TTARCCQLS.

Greater than 98% as determined by SDS-PAGE & RP-HPLC.

Sterile filtered and lyophilized from 0.5mg/ml in 10mM sodium phosphate buffer, pH 7.5. Sterile Filtered White lyophilized (freeze-dried) powder.

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

Solubility: At 0.1mg/ml of deionized sterile water.

CYTOKINES AND GROWTH FACTORS; Cytokines; Resistin

Description: Mouse RELM-alpha Recombinant produced in E Coli is a monomeric, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10 kDa. The Mouse RELM-alpha is purified by proprietary chromatographic techniques. Introduction: Bronchoalveolar lavage fluid from mice with experimentally induced allergic pulmonary inflammation contains a novel 9.4 kDa cysteine-rich secreted protein, RELM-alpha (FIZZ1, found in inflammatory zone). RELM-alpha is a secreted protein that has a restricted tissue distribution with highest levels in adipose tissue stroma. Murine RELM-alpha (FIZZ1) is the founding member of a new gene family including two other murine genes expressed, respectively, in intestinal crypt epithelium (RELM-beta) and white adipose tissue (Resistin), and two related human genes.RELMalpha inhibits the differentiation of 3T3-L1 preadipocytes into adipocytes but has no effect on proliferation of 3T3-L1 preadipocytes. RELMalpha is able to form heterooligomers with resistin but not RELMbeta. Since RELMalpha is expressed by adipose tissue and it is a secreted factor, our findings suggest that RELMalpha may be involved in the control of the adipogenesis as well as in the process of muscle differentiation.In the lung, RELM-alpha is induced by hypoxia and was renamed as hypoxia-induced mitogenic factor (HIMF). HIMF strongly activated Akt phosphorylation. The phosphatidylinositol 3-kinase (PI3K) inhibitor LY294002 (10 micromol/L) inhibited HIMF-activated Akt phosphorylation. It also inhibited HIMF stimulated RPSM proliferation. Thus, the PI3K/Akt pathway, at least in part, mediates the proliferative effect of HIMF. Further studies showed that HIMF had angiogenic and vasoconstrictive properties. HIMF increased pulmonary arterial pressure and vascular resistance. Further studies suggest that HIMF regulates apoptosis and may participate in lung alveolarization and maturation.

103472022

NP_065255.2

NM_020509.3

Q9EP95

11,936 Da

0.005 mg

140 USD

0.025 mg

205

1 mg

2665