protein

Recombinant Human Macrophage Colony Stimulating Factor

MBS142185

0.01 mg

205 USD

Recombinant Protein

Recombinant Human Macrophage Colony Stimulating Factor

Macrophage Colony Stimulating Factor

M CSF Human; Macrophage-Colony Stimulating Factor Human Recombinant; Macrophage Colony Stimulating Factor; CSF-1; Lanimostim; MCSF; MGC31930; M-CSF

macrophage colony-stimulating factor 1 isoform a; Macrophage colony-stimulating factor 1; macrophage colony-stimulating factor 1; lanimostim; colony stimulating factor 1 (macrophage); LanimostimProcessed macrophage colony-stimulating factor 1

M CSF

CSF1; CSF1; MCSF; CSF-1; CSF-1; M-CSF; MCSF

CSF1_HUMAN

E Coli

554

The sequence of the first five N-terminal amino acids of MCSF was determined and found to be Met-Glu-Glu-Val-Ser.

Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The MCSF protein was lyophilized with 10mM sodium Phosphate, pH-8.0 & 50mM NaCl. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized MCSF although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution MCSF should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized MCSF in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50, calculated by the dose-dependent stimulation of the proliferation of murine M-NFS-60 indicator cells was found to be < 2.0ng/ml, corresponding to a specific activity of 500,00Units/mg.

CYTOKINES AND GROWTH FACTORS; Growth Factors; Colony Stimulating Factor

Description: Macrophage Colony Stimulating Factor Human Recombinant produced in E Coli is a disulfide linked homodimer, non-glycosylated, polypeptide chain containing 2 x 159 amino acids and having a total molecular mass of 36.8 KD.MCSF is purified by proprietary chromatographic techniques. Introduction: Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. MCSF induces cells of the monocyte/macrophage lineage. MCSF plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.

27262661

NP_000748.3

NM_000757.5

P09603

29,215 Da

Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Cytokines And Inflammatory Response Pathway 198794!!Hematopoietic Cell Lineage Pathway 83078!!Hematopoietic Cell Lineage Pathway 489!!Integrins In Angiogenesis Pathway 137999!!Osteoclast Differentiation Pathway 193147!!Osteoclast Differentiation Pathway 193096!!PI3K-Akt Signaling Pathway 692234!!PI3K-Akt Signaling Pathway 692979

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]

0.01 mg

205 USD