protein

Recombinant Human BAFF (BLyS)

MBS142184

0.005 mg

140 USD

Recombinant Protein

Recombinant Human BAFF (BLyS)

BAFF

BAFF Human; B-cell Activating Factor Human Recombinant; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20; TNFSF13B; B-cell Activating Factor

tumor necrosis factor ligand superfamily member 13B isoform 2; Tumor necrosis factor ligand superfamily member 13B; tumor necrosis factor ligand superfamily member 13B; ApoL related ligand TALL-1; B-cell-activating factor; B-lymphocyte stimulator; Delta4 BAFF; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; delta BAFF; dendritic cell-derived TNF-like molecule; tumor necrosis factor (ligand) superfamily, member 20; tumor necrosis factor-like protein ZTNF4; tumor necrosis factor (ligand) superfamily, member 13b; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD_antigen: CD257Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form

BAFF

TNFSF13B; TNFSF13B; DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20; BAFF; BLYS; TALL1; TNFSF20; ZTNF4; BLyS; TALL-1

TN13B_HUMAN

E Coli

266

MAVQGPEETV TQDCLQLIAD SETPTIQKGS YTFVPWLLSF KRGSALEEKE NKILVKETGY FFIYGQVLYT DKTYAMGHLI QRKKVHVFGD ELSLVTLFRC IQNMPETLPN NSCYSAGIAK LEEGDELQLA IPRENAQISL DGDVTFFGAL KLL.

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

Lyophilized from a 0.2 um filtered concentrated solution in PBS, pH 7.0. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized BAFF although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution BAFF should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized BAFF in sterile 18M-cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The activity is determined by a mouse splenocyte survival assay. The ED50 for this effect is 0.5-2.0 ug/ml.

CYTOKINES AND GROWTH FACTORS; Cytokines; B-Cell Activating Factor

Description: BAFF Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 153 amino acids and having a molecular mass of 17007 Dalton. The BAFF is purified by proprietary chromatographic techniques. Introduction: BAFF binds to tnfrsf13b/taci and tnfrsf17/bcma. Tnfsf13/april binds to the same 2 receptors, together, they form a 2 ligands -2 receptors pathway involved in the stimulation of b- and t-cell function and the regulation of humoral immunity. A third b-cell specific baff-receptor (baffr/br3) promotes the survival of mature b-cells and the b-cell response.B Lymphocyte Stimulator functions as a potent B-cell growth factor in costimulation assays. Administration of BAFF Human recombinant to mice disrupts splenic B-cell and T-cell zones and results in elevated levels of serum immunoglobulin.

224548983

NP_001139117.1

NM_001145645.2

Q9Y275

17,578 Da

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); NF-kappa B Signaling Pathway (634527); Rheumatoid Arthritis Pathway (200309); Rheumatoid Arthritis Pathway (200269); Spinal Cord Injury Pathway (739007)

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]

BAFF: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Apoptosis; Membrane protein, integral; Cell cycle regulation; Cytokine. Chromosomal Location of Human Ortholog: 13q32-q34. Cellular Component: extracellular space; perinuclear region of cytoplasm; cytoplasm; plasma membrane; integral to membrane. Molecular Function: protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding. Biological Process: cell proliferation; B cell costimulation; B cell homeostasis; immunoglobulin secretion; T cell costimulation; positive regulation of cell proliferation; positive regulation of germinal center formation; positive regulation of B cell proliferation; immune response; positive regulation of T cell proliferation; signal transduction

0.005 mg

140 USD

0.02 mg

205

1 mg

4550