Human Insulin Like Growth Factor Binding Protein-1 | MyBioSource MBS142176 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human Insulin Like Growth Factor Binding Protein-1

catalog :

MBS142176

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142176

products type :

Native Protein

products full name :

Human Insulin Like Growth Factor Binding Protein-1

products short name :

Insulin Like Growth Factor Binding Protein-1

products name syn :

IGFBP 1 Human; Insulin-Like Growth Factor Binding Protein-1 Human; IBP-1; IGF-Binding Protein 1; AFBP; PP12; IGF-BP25; hIGFBP-1; IGFBP-1

other names :

insulin-like growth factor-binding protein 1; Insulin-like growth factor-binding protein 1; insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; alpha-pregnancy-associated endometrial globulin; amniotic fluid binding protein; binding protein-25; binding protein-26; binding protein-28; growth hormone independent-binding protein; placental protein 12; insulin-like growth factor binding protein 1; Placental protein 12; PP12

products gene name :

IGFBP1

other gene names :

IGFBP1; IGFBP1; AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1; IBP1; IBP-1; IGF-binding protein 1; IGFBP-1; PP12

uniprot entry name :

IBP1_HUMAN

host :

Human amniotic fluid

sequence length :

259

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The protein was lyophilized with 10mM HCL. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized IGFBP1 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IGF-BP1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized IBP-1 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: Inhibition of IGF-I stimulated proliferation of NUC-1 cells: IC50 ~ 100 ng/ml Inhibition of serum-induced stimulation of DNA synthesis in chick embryo fibroblast primary cultures: IC50 (1% serum) ~300 ng/ml corresponding to a Specific Activity of 3,334IU/mg.

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors; IGFBP

products description :

Description: IGFBP1 native Human is a single, glycosylated, polypeptide chain containing 218 amino acids and having a molecular mass of 25.3kDa. IGFBP1 is purified by proprietary chromatographic techniques. Introduction: IGFBP1 is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

ncbi gi num :

4504615

ncbi acc num :

NP_000587.1

ncbi gb acc num :

NM_000596.2

uniprot acc num :

P08833

ncbi mol weight :

27,904 Da

ncbi pathways :

ATF4 Activates Genes Pathway (530772); AhR Pathway (755436); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); HIF-1-alpha Transcription Factor Network Pathway (138045); Metabolism Of Proteins Pathway (106230); Myometrial Relaxation And Contraction Pathways (198759); PERK Regulates Gene Expression Pathway (105907); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908); Unfolded Protein Response (UPR) Pathway (105904)

ncbi summary :

This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]

uniprot summary :

IGFBP1: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 7p12.3. Cellular Component: extracellular space; extracellular region. Molecular Function: insulin-like growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding. Biological Process: regulation of insulin-like growth factor receptor signaling pathway; unfolded protein response, activation of signaling protein activity; cellular protein metabolic process; tissue regeneration; unfolded protein response; insulin receptor signaling pathway; signal transduction; positive regulation of cell growth

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage