protein

Recombinant Human Interferon Regulatory Factor-3

MBS142169

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Interferon Regulatory Factor-3

Interferon Regulatory Factor-3

IRF 3 Human; Interferon Regulatory Factor-3 Human Recombinant; IRF-3; IRF3; Interferon Regulatory Factor 3

interferon regulatory factor 3 isoform 2; Interferon regulatory factor 3; interferon regulatory factor 3; interferon regulatory factor 3

IRF 3

IRF3; IRF3; IRF-3

IRF3_HUMAN

E Coli

452

MGTPKPRILP WLVSQLDLGQ LEGVAWVNKS RTRFRIPWKH GLRQDAQQED FGIFQAWAEA TGAYVPGRDK PDLPTWKRNF RSALNRKEGL RLAEDRSKDP HDPHKIYEFV NS.

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

1mg/ml in phosphate-buffered saline (PBS), pH 7.4. Sterile Filtered colorless solution.

Liquid Interferon although stable at 10 degree C for 1 week, should be stored below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

CYTOKINES AND GROWTH FACTORS; Cytokines; Interferon

Description: IRF-3 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 111 amino acids (1-112) and having a molecular mass of 13 kDa.The Interferon Regulatory Factor-3 is purified by proprietary chromatographic techniques. Introduction: Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF-3 mediates interferon-stimulated response element (isre) promoter activation. Functions as a molecular switch for antiviral activity. Dsrna generated during the course of an viral infection leads to IRF3 phosphorylation on the c-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with creb binding protein (crebbp) to form dsrna-activated factor 1 (draf1), a complex which activates the transcription of genes under the control of isre. The complex binds to the ie and prdiii regions on the ifn-alpha and ifn-beta promoters respectively. IRF-3 does not have any transcription activation domains.

308199446

NP_001184051.1

NM_001197122.1

Q14653

12,330 Da

Activated TLR4 Signalling Pathway (106400); Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway (187088); Antiviral Mechanism By IFN-stimulated Genes Pathway (530760); Apoptosis Pathway (198797); Cytokine Signaling In Immune System Pathway (366171); Cytosolic DNA-sensing Pathway (125137); Cytosolic DNA-sensing Pathway (124833); Cytosolic Sensors Of Pathogen-associated DNA Pathway (576255); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115)

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

IRF3: interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 19q13.3-q13.4. Cellular Component: nucleoplasm; cytoplasm; cytosol; nucleus. Molecular Function: identical protein binding; protein binding; protein homodimerization activity; DNA binding; transcription cofactor activity; transcription factor activity. Biological Process: transcription from RNA polymerase II promoter; negative regulation of interferon-beta biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; apoptosis; cytokine and chemokine mediated signaling pathway; MyD88-independent toll-like receptor signaling pathway; negative regulation of transcription from RNA polymerase II promoter; toll-like receptor 3 signaling pathway; negative regulation of defense response to virus by host; response to exogenous dsRNA; positive regulation of interferon type I production; positive regulation of interferon-beta production; toll-like receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; innate immune response; interferon type I biosynthetic process; response to DNA damage stimulus; toll-like receptor 4 signaling pathway; defense response to virus; negative regulation of interferon type I production; positive regulation of interferon-alpha production; positive regulation of cytokine secretion. Disease: Herpes Simplex Encephalitis, Susceptibility To, 7

0.005 mg

140 USD

0.02 mg

205

1 mg

2665