catalog number :
MBS142144
products type :
Recombinant Protein
products full name :
Recombinant Human Prolactin
products short name :
Prolactin
products name syn :
Prolactin Human; Prolactin Human Recombinant; Mammotropin; Luteotropic hormone; Luteotropin; PRL; Prolactin
other names :
prolactin; Prolactin; prolactin; decidual prolactin; prolactin; N/A
other gene names :
PRL; PRL; PRL
uniprot entry name :
PRL_HUMAN
sequence :
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Leu-Pro-Ile-Cys.
purity :
Greater than 95.0% as determined by: (a) Analysis by SEC-HPLC. (b) Analysis by SDS-PAGE.
form :
The protein was lyophilized from a concentrated (1mg/ml) solution with 10mM sodium Phosphate buffer pH=8 and 50mM Nacl. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized Prolactin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Prolactin should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized Prolactin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of rat lymphoma, Nb2-11 was found to be < 0.065ng/ml corresponding to a Specific Activity of 15,385,000IU/mg.
products categories :
CYTOKINES AND GROWTH FACTORS; Growth Factors; Prolactin
products description :
Description: Prolactin Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 200 amino acids and having a molecular mass of 23007 Dalton. The Prolactin is purified by proprietary chromatographic techniques. Introduction: Prolactin is a neuroendocrine hormone synthesized primarily by the pituitary gland but also a variety of other cell types including the placenta, brain and uterus. Its primary function is to promote and maintain lactation but has also been shown to have a role in breast cancer development, regulation of reproductive function and immunoregulation.
ncbi acc num :
NP_000939.1
ncbi gb acc num :
NM_000948.5
ncbi mol weight :
25,876 Da
ncbi pathways :
Amyloids Pathway 366238!!Cytokine Signaling In Immune System Pathway 366171!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Disease Pathway 530764!!ErbB4 Signaling Events Pathway 137991!!Glucocorticoid Receptor Regulatory Network Pathway 138014!!Growth Hormone Receptor Signaling Pathway 477128!!Immune System Pathway 106386!!Jak-STAT Signaling Pathway 83077
ncbi summary :
This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]