catalog number :
MBS142138
products type :
Recombinant Protein
products full name :
Recombinant Human Bone Morphogenetic protein-2
products short name :
Morphogenetic protein-2
products name syn :
BMP 2 Human; Bone Morphogenetic Protein-2 Human Recombinant; BMP-2; BMP2A
other names :
bone morphogenetic protein 2 preproprotein; Bone morphogenetic protein 2; bone morphogenetic protein 2; BMP-2A; bone morphogenetic protein 2A; bone morphogenetic protein 2; Bone morphogenetic protein 2A; BMP-2A
products gene name :
BMP 2
other gene names :
BMP2; BMP2; BDA2; BMP2A; BMP2A; BMP-2; BMP-2A
uniprot entry name :
BMP2_HUMAN
sequence :
MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR.
purity :
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
BMP2 was lyophilized from a concentrated (1mg/ml) sterile solution containing 10mM sodium citrate pH=3.5. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized Bone Morphogenetic Protein-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution BMP2 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
other info2 :
Protein Content: Protein quantitation was carried out by two independent methods:1. UV spectroscopy at 280 nm using the absorbency value of 1.4 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a standard solution of BMP-2 as a Reference Standard. Biological Activity: The ED50 as determined by its ability to induce alkaline phosphatase production by ATDC-5 cells is 0.5-1.0 ug/ml.
products categories :
CYTOKINES AND GROWTH FACTORS; Cytokines; Bone Morphogenetic Protein
products description :
Description: Bone Morphogenetic Protein-2 Human Recombinant produced in E Coli is a homodimeric, non-glycosylated polypeptide chain containing 2x115 amino acids and having a molecular mass of 26kDa. The BMP-2 is purified by proprietary chromatographic techniques. Introduction: BMP2 belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva.
ncbi acc num :
NP_001191.1
ncbi gb acc num :
NM_001200.2
ncbi mol weight :
44,702 Da
ncbi pathways :
Adipogenesis Pathway (198832); BDNF Signaling Pathway (712093); BMP Signaling Pathway (1084755); BMP Signaling Pathway (1108218); BMP Signalling And Regulation Pathway (198910); Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Elastic Fibre Formation Pathway (730310)
ncbi summary :
The protein encoded by this gene belongs to the transforming growth factor-beta (TGFB) superfamily. The encoded protein acts as a disulfide-linked homodimer and induces bone and cartilage formation. [provided by RefSeq, Jul 2008]