Recombinant Human Resistin, His Tag | MyBioSource MBS142133 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Resistin, His Tag

catalog :

MBS142133

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142133

products type :

Recombinant Protein

products full name :

Recombinant Human Resistin, His Tag

products short name :

Resistin

products name syn :

Resistin Human, His; Resistin Human Recombinant, His Tag; Cysteine-rich secreted protein FIZZ3; Adipose tissue-specific secretory factor; ADSF; C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 2; RSTN; XCP1; RETN1; MGC126603; MGC126609; Resistin His

other names :

resistin; Resistin; resistin; C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1; adipose tissue-specific secretory factor; c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; cysteine-rich secreted protein A12-alpha-like 2; cysteine-rich secreted protein FIZZ3; found in inflammatory zone 3; resistin delta2; resistin; Adipose tissue-specific secretory factor; ADSF; C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein; Cysteine-rich secreted protein A12-alpha-like 2; Cysteine-rich secreted protein FIZZ3

other gene names :

RETN; RETN; ADSF; RSTN; XCP1; FIZZ3; RETN1; FIZZ3; HXCP1; RSTN; ADSF

uniprot entry name :

RETN_HUMAN

host :

E Coli

sequence length :

108

purity :

Greater than 95% as determined by SDS-PAGE.

form :

Resistin protein (0.14mg/ml) is supplied in 20mM Tris-HCl pH 8.0, 5mM EDTA and 50% glycerol. Sterile filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time.Please avoid freeze thaw cycles.

products categories :

CYTOKINES AND GROWTH FACTORS; Cytokines; Resistin

products description :

Description: Resistin Human Recombinant produced in E Coli is a single, non-glycosylated, Polypeptide chain containing a 92 amino acids fragment (17-108) of the mature Human Resistin, having a total molecular mass of 14.23kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The Resistin is purified by proprietary chromatographic techniques. Introduction: Resistin, a product of the RSTN gene, is a peptide hormone belonging to the class of cysteine-rich secreted proteins which is termed the RELM family, and is also described as ADSF (Adipose Tissue- Specific Secretory Factor) and FIZZ3 (Found in Inflammatory Zone). Human resistin contains 108 amino acids as a prepeptide, and its hydrofobic signal peptide is cleaved before its secretion. Resistin circulates in human blood as a dimeric protein consisting of two 92 amino acid polypeptides, which are disulfide-linked via Cys26.Resistin may be an important link between obesity and insulin resistance. Mouse resistin, specifically produced and secreted by adipocyte, acts on skeletal muscle myocytes, hepatocytes and adipocytes themselves so that it reduces their sensitivity to insulin. Steppan et al. have suggested that resistin suppresses the ability of insulin to stimulate glucose uptake. They have also suggested that resistin is present at elevated levels in blood of obese mice, and is down regulated by fasting and antidiabetic drugs. Way et al., on the other hand, have found that resistin expression is severly suppressed in obesity and is stimulated by several antidiabetic drugs.Other studies have shown that mouse resistin increases during the differentiation of adipocytes, but it also seems to inhibit adipogenesis. In contrast, the human adipogenic differentiation is likely to be associated with a down regulation of resistin gene expression.

ncbi gi num :

301129180

ncbi acc num :

NP_001180303.1

ncbi gb acc num :

NM_001193374.1

uniprot acc num :

Q9HD89

ncbi mol weight :

8,686 Da

ncbi pathways :

Adipogenesis Pathway (198832)

ncbi summary :

This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2010]

uniprot summary :

resistin: Hormone that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. Potentially links obesity to diabetes. Belongs to the resistin/FIZZ family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 19p13.2. Cellular Component: extracellular space; nucleus. Molecular Function: hormone activity. Biological Process: fat cell differentiation; response to mechanical stimulus; positive regulation of smooth muscle cell proliferation; positive regulation of smooth muscle cell migration; positive regulation of synaptic transmission; response to insulin stimulus; aging. Disease: Diabetes Mellitus, Noninsulin-dependent

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.025 mg

price2 :

205

size3 :

1 mg

price3 :

3600

more info or order :

MyBioSource product webpage