Recombinant Human Angiopoietin-like Protein 3 | MyBioSource MBS142125 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Angiopoietin-like Protein 3

catalog :

MBS142125

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142125

products type :

Recombinant Protein

products full name :

Recombinant Human Angiopoietin-like Protein 3

products short name :

Angiopoietin-like Protein 3

products name syn :

ANGPTL3 Human; Angiopoietin Like Protein 3 Human Recombinant; Angiopoietin 5; ANGPT5; ANGPTL3; Angiopoietin Like Protein 3

other names :

angiopoietin-related protein 3 preproprotein; Angiopoietin-related protein 3; angiopoietin-related protein 3; angiopoietin 5; angiopoietin-like 3; Angiopoietin-5; ANG-5; Angiopoietin-like protein 3

products gene name :

ANGPTL3

other gene names :

ANGPTL3; ANGPTL3; ANL3; ANG-5; FHBL2; ANGPT5; ANGPT5; ANG-5

uniprot entry name :

ANGL3_HUMAN

host :

E Coli

sequence length :

460

purity :

Angiopoietin 5 purity is greater than 95% as determined by SDS-PAGE.

form :

ANGPTL3 Human filtered and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer pH-4.

storage stability :

Store lyophilized ANGPTL3 Human at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted Angiopoietin 5 can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

other info2 :

Solubility: Add 0.2 ml of 0.1M Acetate buffer pH-4 and let the lyophilized pellet of ANGPTL3 Human dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10ug/ml. In higher concentrations the solubility of Angiopoietin 5 is limited.

products categories :

CYTOKINES AND GROWTH FACTORS; Cytokines; Angiopoietin

products description :

Description: The ANGPTL3 Human Recombinant is produced with N-terminal fusion of His-Tag. The Angiopoietin-like protein 3 His Tagged Fusion Protein is 26kDa containing 207 amino acid residues of the ANGPTL3 Human and 16 additional amino acid residues His-Tag (underlined). Introduction: ANGPTL3 and ANGPTL4 are angiopoietin-like proteins secreted and expressed mainly by the liver, their role being the regulation of triglyceride metabolism by inhibiting the lipolysis of triglyceride-rich lipoproteins. During different nutritional states (feeding/fasting) the levels of the circulating triglycerides are regulated by Angptl3 and Angptl4 through differential inhibition of Lipoprotein lipase (LPL) as shown by the experimental data. The molecular structure of ANGPTL3 is similar to that of the angiopoietins (vascular endothelial growth factors). Deletion mutants of human Angiopoietin 5 were used in order to demonstrate that the N-terminal domain (fragment 17-207) and not the C-terminal fibrinogen-like domain (fragment 207-460) increased the plasma triglyceride levels in mice.

ncbi gi num :

7656888

ncbi acc num :

NP_055310.1

ncbi gb acc num :

NM_014495.3

uniprot acc num :

Q9Y5C1

ncbi mol weight :

53,637 Da

ncbi pathways :

Integrins In Angiogenesis Pathway (137999)

ncbi summary :

This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Feb 2013]

uniprot summary :

ANGPTL3: Defects in ANGPTL3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2); also called combined hypobetalipoproteinemia familial. FHBL2 is a disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides. Protein type: Secreted, signal peptide; Inhibitor; Motility/polarity/chemotaxis; Secreted; Cell adhesion. Chromosomal Location of Human Ortholog: 1p31.3. Cellular Component: extracellular space; cell surface. Molecular Function: integrin binding; enzyme inhibitor activity; phospholipase inhibitor activity; growth factor activity. Biological Process: integrin-mediated signaling pathway; cholesterol metabolic process; glycerol metabolic process; phospholipid catabolic process; cell-matrix adhesion; lipid homeostasis; positive regulation of lipid catabolic process; fatty acid metabolic process; signal transduction; positive regulation of angiogenesis; sequestering of lipid; cholesterol homeostasis; acylglycerol homeostasis; phospholipid metabolic process; artery morphogenesis; negative regulation of lipoprotein lipase activity; phospholipid homeostasis; positive regulation of cell migration. Disease: Hypobetalipoproteinemia, Familial, 2

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5230

more info or order :

MyBioSource product webpage