Recombinant Human Follistatin | MyBioSource MBS142109 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Follistatin

catalog :

MBS142109

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142109

products type :

Recombinant Protein

products full name :

Recombinant Human Follistatin

products short name :

Follistatin

products name syn :

FST Human; Follistatin Human Recombinant; FST; FS; Activin-binding protein

other names :

follistatin isoform FST317; Follistatin; follistatin; activin-binding protein; follistatin isoform FST317; follistatin; Activin-binding protein

products gene name :

FST

other gene names :

FST; FST; FS; FS

uniprot entry name :

FST_HUMAN

host :

E Coli

sequence length :

317

sequence :

The sequence of the first five N-terminal amino acids was determined and was found to be Gly-Asn-Cys-Trp-Leu.

purity :

Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

Lyophilized from a concentrated (1mg/ml) solution containing no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized Follistatin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution FST should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Follistatin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The activity is determined by the ability to neutralize Activin A inhibitory effect of mouse MPC-11 cells. The expected ED50 is 100-400ng/ml, corresponding to a Specific Activity of 2,500-10,000units/mg in the presence of 7.5ng/ml Activin A.

products categories :

CYTOKINES AND GROWTH FACTORS; Cytokines; Follistatin

products description :

Description: Follistatin Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 288 amino acids and having a total molecular mass of 31.5kDa.The FST is purified by proprietary chromatographic techniques. Introduction: Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. Follistatin binds directly to activin and functions as an activin antagonist. specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (fsh).

ncbi gi num :

5453652

ncbi acc num :

NP_006341.1

ncbi gb acc num :

NM_006350.3

uniprot acc num :

P19883

ncbi mol weight :

34,803 Da

ncbi pathways :

Antagonism Of Activin By Follistatin Pathway (730350); BMP Receptor Signaling Pathway (137948); Integrated Pancreatic Cancer Pathway (711360); Signal Transduction Pathway (477114); Signaling By Activin Pathway (730349); TGF Beta Signaling Pathway (198810); TGF-beta Signaling Pathway (83064); TGF-beta Signaling Pathway (475)

ncbi summary :

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin. [provided by RefSeq, Jul 2008]

uniprot summary :

FST: Binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH). 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 5q11.2. Cellular Component: cytoplasm; extracellular region; nucleus. Molecular Function: heparan sulfate proteoglycan binding; protein binding; signal transducer activity; activin binding. Biological Process: BMP signaling pathway; positive regulation of hair follicle development; negative regulation of activin receptor signaling pathway; negative regulation of cell differentiation; hair follicle morphogenesis; gamete generation; hemopoietic progenitor cell differentiation; keratinocyte proliferation; negative regulation of transcription from RNA polymerase II promoter; skeletal development; pattern specification process; female gonad development; odontogenesis of dentine-containing teeth. Disease: Polycystic Ovary Syndrome 1

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

4550

more info or order :

MyBioSource product webpage