Recombinant Mouse Granulocyte Macrophage-Colony Stimulating Factor | MyBioSource MBS142099 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Mouse Granulocyte Macrophage-Colony Stimulating Factor

catalog :

MBS142099

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142099

products type :

Recombinant Protein

products full name :

Recombinant Mouse Granulocyte Macrophage-Colony Stimulating Factor

products short name :

[Granulocyte Macrophage-Colony Stimulating Factor]

products name syn :

[GM CSF Mouse; Granulocyte Macrophage-Colony Stimulating Factor Mouse Recombinant; CSF-2; MGI-1GM; GM-CSF; Pluripoietin-alpha; Molgramostin; Sargramostim]

other names :

[granulocyte-macrophage colony-stimulating factor; Granulocyte-macrophage colony-stimulating factor; granulocyte-macrophage colony-stimulating factor; CSF; granulocyte-macrophage colony stimulating factor 2; put. GM-CSF; colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF]

products gene name :

[mGM CSF]

other gene names :

[Csf2; Csf2; Csfgm; GMCSF; Gm-CSf; MGI-IGM; Csfgm; GM-CSF; CSF]

uniprot entry name :

CSF2_MOUSE

sequence length :

141

sequence :

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Pro-Thr-Arg

purity :

Greater than 98.0% as determined by . (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

GM-CSF Mouse was lyophilized with no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized Granulocyte Macrophage Colony Stimulating Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution GM-CSF should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info1 :

Source: E Coli

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Granulocyte Macrophage Colony Stimulating Factor in sterile 20mM AcOH (acetic Acid) not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Protein Content: GM-CSF quantitation was carried out by two independent methods. 1. UV spectroscopy at 280 nm using the absorbency value of 0.765 as the extinction coefficient for a 0.1% (1mg/ml) solution. This value is calculated by the PC GENE computer analysis program of protein sequences (IntelliGenetics). 2. Analysis by RP-HPLC, using a calibrated solution of GM-CSF as a Reference Standard. Biological Activity: The ED 50 as determined by the dose-dependant stimulation of the proliferation of murine FDC-P1 cell line is 6 IU/mg.

products categories :

CYTOKINES AND GROWTH FACTORS; Growth Factors; Colony Stimulating Factor

products description :

Description: Granulocyte Macrophage Colony Stimulating Factor Mouse Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 125 amino acids and having a molecular mass of 14285.35 Dalton.GM-CSF Mouse is purified by proprietary chromatographic techniques. Introduction: GMCSF is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.GM-CSF stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

ncbi gi num :

110625658

ncbi acc num :

NP_034099.2

ncbi gb acc num :

NM_009969.4

uniprot acc num :

P01587

ncbi mol weight :

16,091 Da

ncbi pathways :

Amoebiasis Pathway (167330); Amoebiasis Pathway (167191); Cytokine Signaling In Immune System Pathway (1110778); Cytokine-cytokine Receptor Interaction Pathway (83248); Cytokine-cytokine Receptor Interaction Pathway (460); Cytokines And Inflammatory Response (BioCarta) Pathway (198283); Fc Epsilon RI Signaling Pathway (83279); Fc Epsilon RI Signaling Pathway (493); G Beta:gamma Signalling Through PI3Kgamma Pathway (1110535); G-protein Beta:gamma Signalling Pathway (1110534)

uniprot summary :

GMCSF: Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. Belongs to the GM-CSF family. Protein type: Secreted; Cytokine; Secreted, signal peptide. Cellular Component: extracellular space; extracellular region. Molecular Function: growth factor activity; granulocyte macrophage colony-stimulating factor receptor binding; cytokine activity. Biological Process: negative regulation of cytolysis; epithelial fluid transport; embryonic placenta development; macrophage activation; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of gene expression; positive regulation of interleukin-23 production; positive regulation of cell proliferation; myeloid dendritic cell differentiation; immune response; positive regulation of DNA replication; regulation of cell proliferation

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2870

more info or order :

MyBioSource product webpage