Recombinant Human Interleukin-5 | MyBioSource MBS142089 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Interleukin-5

catalog :

MBS142089

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142089

products type :

Recombinant Protein

products full name :

Recombinant Human Interleukin-5

products short name :

Interleukin-5

products name syn :

IL 5 Human; Interleukin-5 Human Recombinant; EDF; BCDFII; TRF; T-cell replacing factor; Eosinophil differentiation factor; B cell differentiation factor I; IL-5

other names :

interleukin-5; Interleukin-5; interleukin-5; B-cell differentiation factor I; T-cell replacing factor; colony-stimulating factor, eosinophil; eosinophil differentiation factor; interleukin 5; B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor; TRF

products gene name :

IL-5

other gene names :

IL5; IL5; EDF; TRF; IL-5; IL-5; TRF

uniprot entry name :

IL5_HUMAN

host :

E Coli

sequence length :

134

sequence :

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ile-Pro-Thr-Glu.

purity :

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

Lyophilized from a concentrated (1mg/ml) solution in water containing no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized Interleukin-5 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution IL5 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please avoid freeze thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Interleikin-5 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of TF-1 cells was found to be < 0.15ng/ml, corresponding to a Specific Activity of 6 x 106 IU/mg.

products categories :

CYTOKINES AND GROWTH FACTORS; Cytokines; Interleukin

products description :

Description: Interleukin-5 Human Recombinant produced in E Coli is a dimeric, non-glycosylated polypeptide chain containing two 113 amino acids chains, and having a molecular mass of 26522.84 Dalton. The IL-5 is purified by proprietary chromatographic techniques. Introduction: The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.

ncbi gi num :

4504671

ncbi acc num :

NP_000870.1

ncbi gb acc num :

NM_000879.2

uniprot acc num :

P05113

ncbi mol weight :

15,238 Da

ncbi pathways :

Allograft Rejection Pathway (920963); Allograft Rejection Pathway (83123); Allograft Rejection Pathway (535); Asthma Pathway (83120); Asthma Pathway (532); Autoimmune Thyroid Disease Pathway (83121); Autoimmune Thyroid Disease Pathway (533); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Cytokine Signaling In Immune System Pathway (366171); Cytokine-cytokine Receptor Interaction Pathway (83051)

ncbi summary :

This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]

uniprot summary :

IL5: Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. Belongs to the IL-5 family. Protein type: Secreted; Secreted, signal peptide; Cytokine. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: extracellular space; extracellular region. Molecular Function: protein binding; interleukin-5 receptor binding; growth factor activity; cytokine activity. Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of B cell proliferation; positive regulation of JAK-STAT cascade; positive regulation of transcription factor activity; immune response; positive regulation of immunoglobulin secretion; inflammatory response; positive regulation of eosinophil differentiation

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

3735

more info or order :

MyBioSource product webpage