Recombinant Human Creatine Kinase Muscle Type-3 | MyBioSource MBS142068 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Creatine Kinase Muscle Type-3

catalog :

MBS142068

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142068

products type :

Recombinant Protein

products full name :

Recombinant Human Creatine Kinase Muscle Type-3

products short name :

Creatine Kinase Muscle Type-3

products name syn :

CKMT3 Human; Creatine Kinase Muscle Type-3 Human Recombinant; Creatine kinase M-type; EC 2.7.3.2; Creatine kinase M chain; M-CK; CKM; CKMM; CKMMITIII; CKM Type-3

other names :

creatine kinase M-type; Creatine kinase M-type; creatine kinase M-type; creatine kinase M chain; creatine kinase, muscle; Creatine kinase M chain; M-CKCreatine kinase M-type, N-terminally processed

products gene name :

CKM

other gene names :

CKM; CKM; CKMM; M-CK; CKMM

uniprot entry name :

KCRM_HUMAN

host :

Pichia Pastoris

sequence length :

381

purity :

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

Each mg of protein contains 20mM Tris pH-8, 1mM EDTA and 1mM DTT. Sterile Filtered colorless liquid formulation.

storage stability :

CKMT3 although stable at 15 degree C for 7 days, should be stored below -18 degree C. Please prevent freeze-thaw cycles.

other info2 :

Biological Activity: The biological activity measured by the enzymatic activity of Creatine phosphokinase procedure No.45-UV, 1IU-1 umole creatine phosphate was 500 IU/mg at 37 degrees celsius corresponding to a Specific Activity of 2,000ng/ml.

products categories :

PROTEIN KINASES; Enzymes; Creatin Kinases

products description :

Description: CKMT3 Human Recombinant produced in Pichia Pastoris is a glycosylated polypeptide chain having an identical amino acid sequence compared to the native enzyme, purified under non-denaturing conditions and reacts with polyclonal antibodies to MM Isoenzyme in ELISA.The CKMT3 is purified by proprietary chromatographic techniques. Introduction: The three isoenzymes (MM, MB, and BB) are found in muscle, cardiac and brain tissues. These recombinant proteins are ideal for calibrating diagnostic instruments and researching neuromuscular diseases. Creatine Kinases can be used for indications in many neuromuscular applications. These disorders include cardiac disease, mitochondrial disorders, inflammatory myopathies, myasthenia, polymyositis, McArdle's disease, NMJ disorders, muscular dystrophy, ALS, hypo and hyperthyroid disorders, central core disease, acid maltase deficiency, myoglobinuria, rhabdomyolysis, motor neuron diseases, rheumatic diseases, and other that create elevated or reduced levels of Creatine Kinases.

ncbi gi num :

21536288

ncbi acc num :

NP_001815.2

ncbi gb acc num :

NM_001824.4

uniprot acc num :

P06732

ncbi mol weight :

43,101 Da

ncbi pathways :

Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Creatine Metabolism Pathway (106192); Creatine Pathway (413359); Creatine Pathway (468234); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Regulation Of Retinoblastoma Protein Pathway (137916); Urea Cycle And Metabolism Of Amino Groups Pathway (198758)

ncbi summary :

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]

uniprot summary :

CKM: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family. Protein type: Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; Kinase, other. Chromosomal Location of Human Ortholog: 19q13.32. Cellular Component: cytosol. Molecular Function: creatine kinase activity; ATP binding. Biological Process: phosphocreatine biosynthetic process; creatine metabolic process; phosphorylation

size1 :

0.01 mg

price1 :

140 USD

size2 :

0.05 mg

price2 :

205

size3 :

1 mg

price3 :

980

more info or order :

MyBioSource product webpage