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Recombinant Rat Macrophage Inflammatory protein-1 alpha (CCL3)

MBS142050

0.02 mg

205 USD

MBS142050

Recombinant Protein

Recombinant Rat Macrophage Inflammatory protein-1 alpha (CCL3)

Macrophage Inflammatory protein-1 alpha

MIP 1a Rat; Macrophage Inflammatory Protein-1 Alpha Rat Recombinant (CCL3); Small inducible cytokine A3; CCL3; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; Tonsillar lymphocyte LD78 alpha protein; G0/G1 switch regulatory protein 19-1; G0S19-1 protein; SIS-beta; PAT 464.1; chemokine (C-C motif) ligand 3; MIP1A; SCYA3; G0S19-1; LD78ALPHA

C-C motif chemokine 3; C-C motif chemokine 3; C-C motif chemokine 3; MIP-1-alpha; Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3); macrophage inflammatory protein 1-alpha; small inducible cytokine A3; small-inducible cytokine A3; chemokine (C-C motif) ligand 3; Macrophage inflammatory protein 1-alpha; MIP-1-alpha; Small-inducible cytokine A3

rMIP 1a

Ccl3; Ccl3; Scya3; MIP-1a; Mip1a; Scya3; MIP-1-alpha

CCL3_RAT

E Coli

92

The sequence of the first five N-terminal amino acids was determined and was found to be, Ala-Pro-Tyr-Gly-Ala.

Greater than 97.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The protein was lyophilized from 1 mg/ml solution containing no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized MIP-1a although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL3 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized Macrophage Inflammatory Protein-1a in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The Activity is calculated by the ability to chemoattract of rat peritoneal macrophages using a conc. of 60 ng/ml corresponding to a Specific Activity of 16,667IU/mg.

CHEMOKINES; Chemokines; MIP

Description: Macrophage Inflammatory Protein-1 alpha Rat Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 69 amino acids and having a molecular mass of 7853 Dalton. The MIP-1a is purified by proprietary chromatographic techniques. Introduction: Macrophage Inflammatory Proteins (MIP) belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1a and MIP-1b that are now officially named CCL3 and CCL4 respectively. Both are major factors produced by macrophages after they are stimulated with bacterial endotoxins. They activate human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. They also induce the synthesis and release of other pro-inflammatory cytokines such as interleukin 1 (IL-1), IL-6 and TNF-a from fibroblasts and macrophages. The genes for CCL3 and CCL4 are both located on human chromosome 17.

40254794

NP_037157.2

NM_013025.2

P50229

10,335 Da

Chagas Disease (American Trypanosomiasis) Pathway 147806!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Chemokine Receptors Bind Chemokines Pathway 1120716!!Chemokine Signaling Pathway 98755!!Chemokine Signaling Pathway 96864!!Class A/1 (Rhodopsin-like Receptors) Pathway 1120714!!Cytokine-cytokine Receptor Interaction Pathway 83443!!Cytokine-cytokine Receptor Interaction Pathway 460!!Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway 1122016!!Disease Pathway 1121849

mediates monocyte and neutrophil chemotaxis; may play a role in the pathogenesis of acute lung injury [RGD, Feb 2006]

0.02 mg

205 USD