Recombinant Human Monocyte Chemotactic Protein-3 (CCL7) | MyBioSource MBS142026 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Monocyte Chemotactic Protein-3 (CCL7)

catalog :

MBS142026

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142026

products type :

Recombinant Protein

products full name :

Recombinant Human Monocyte Chemotactic Protein-3 (CCL7)

products short name :

Monocyte Chemotactic Protein-3

products name syn :

MCP 3 Human; Monocyte Chemotactic Protein-3 Human Recombinant (CCL7); Small inducible cytokine A7; CCL7; Monocyte chemotactic protein 3; MCP-3; Monocyte chemoattractant protein 3; NC28; chemokine (C-C motif) ligand 7; FIC; MARC; MCP3; SCYA6; SCYA7; MGC138463; MGC138465

other names :

C-C motif chemokine 7; C-C motif chemokine 7; C-C motif chemokine 7; monocyte chemoattractant protein 3; monocyte chemotactic protein 3; small inducible cytokine A7 (monocyte chemotactic protein 3); small-inducible cytokine A7; chemokine (C-C motif) ligand 7; Monocyte chemoattractant protein 3; Monocyte chemotactic protein 3; MCP-3; NC28; Small-inducible cytokine A7

products gene name :

MCP 3

other gene names :

CCL7; CCL7; FIC; MARC; MCP3; NC28; MCP-3; SCYA6; SCYA7; MCP3; SCYA6; SCYA7; MCP-3

uniprot entry name :

CCL7_HUMAN

host :

E Coli

sequence length :

sequence :

The sequence of the first five N-terminal amino acids was determined and was found to be Gln-Pro-Val-Gly-Ile.

purity :

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The protein was lyophilized from a concentrated (1mg/ml) sterile solution containing no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized MCP-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL7 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Monocyte Chemotactic Protein-3in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The specific activity as determined by the ability of MCP-3 to chemoattract human peripheral blood at 8 - 80ng/ml corresponding to a Specific Activity of 12,500-125,000IU/mg.

products categories :

CHEMOKINES; Chemokines; MCP

products description :

Description: Monocyte Chemotactic Protein-3 Human Recombinant produced in E Coli is a non-glycosylated, Polypeptide chain containing 76 amino acids and having a molecular mass of 9011 Dalton. The MCP-3 is purified by proprietary chromatographic techniques. Introduction: Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3). Due to CCL7 possessing two adjacent N-terminal cysteine residues in its mature protein, it is classified among the subfamily of chemokines known as CC chemokines. CCL7 specifically attracts monocytes, and regulates macrophage function. It is produced by certain tumor cell lines and by macrophages. This chemokine is located on chromosome 17 in humans, in a large cluster containing many other CC chemokines and is most closely related to CCL2(previously called MCP1).

ncbi gi num :

13435402

ncbi acc num :

NP_006264.2

ncbi gb acc num :

NM_006273.3

uniprot acc num :

P80098

ncbi mol weight :

11,200 Da

ncbi pathways :

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); GPCR Ligand Binding Pathway (161020); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637)

ncbi summary :

This gene encodes monocyte chemotactic protein 3, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. [provided by RefSeq, Jul 2008]

uniprot summary :

CCL7: Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3. Belongs to the intercrine beta (chemokine CC) family. Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 17q11.2-q12. Cellular Component: extracellular space; extracellular region. Molecular Function: heparin binding; CCR1 chemokine receptor binding; CCR2 chemokine receptor binding; chemokine activity. Biological Process: cellular calcium ion homeostasis; regulation of cell shape; monocyte chemotaxis; cell-cell signaling; eosinophil chemotaxis; response to gamma radiation; immune response; cytoskeleton organization and biogenesis; inflammatory response; signal transduction; chemotaxis; positive regulation of cell migration

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

3735

more info or order :

MyBioSource product webpage