Recombinant Human Lymphotactin (XCL1) | MyBioSource MBS142023 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Lymphotactin (XCL1)

catalog :

MBS142023

quantity :

0.006 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142023

products type :

Recombinant Protein

products full name :

Recombinant Human Lymphotactin (XCL1)

products short name :

Lymphotactin

products name syn :

Lymphotactin Human; Lymphotactin Human Recombinant (XCL1); XCL1; Cytokine SCM-1; ATAC; Lymphotaxin; SCM-1-alpha; Small inducible cytokine C1; XC chemokine ligand 1; LTN; LPTN; SCM1; SCM-1; SCYC1; SCM-1a; Lymphotactin

other names :

lymphotactin; Lymphotactin; lymphotactin; SCM-1-alpha; XC chemokine ligand 1; c motif chemokine 1; cytokine SCM-1; lymphotaxin; single cysteine motif 1a; small inducible cytokine subfamily C, member 1 (lymphotactin); small-inducible cytokine C1; chemokine (C motif) ligand 1; ATAC; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; SCM-1-alpha; Small-inducible cytokine C1; XC chemokine ligand 1

other gene names :

XCL1; XCL1; LTN; ATAC; LPTN; SCM1; SCM-1; SCM1A; SCYC1; SCM-1a; LTN; SCYC1

uniprot entry name :

XCL1_HUMAN

host :

E Coli

sequence length :

114

sequence :

The sequence of the first five N-terminal amino acids was determined and was found to be Gln-Ser-Glu-Val-Ser.

purity :

Greater than 99.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The XCL1 was lyophilized from a concentrated (1mg/ml) solution in water containing no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized Lymphotactin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution XCL1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Lymphotactin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The Biological activity is calculated by its ability to chemoattract human T cells at 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

products categories :

CHEMOKINES; Chemokines; Lymphotactin (XCL1)

products description :

Description: Lymphotactin Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 92 amino acids and having a molecular mass of 10007 Dalton. The Lymphotactin is purified by proprietary chromatographic techniques. Introduction: Chemokine (C motif) ligand (XCL1) is a small cytokine belonging to the XC chemokine family that is also known as lymphotactin. It is found in high levels in spleen, thymus, intestine and peripheral blood leukocytes, and at lower levels in lung, prostate gland and ovary. Cellular sources for XCL1 include activated thymic and peripheral blood CD8+ T cells. This chemokine attracts T cells. In humans, XCL1 is closely related to another chemokine called XCL2, whose geneis found at the same locus on chromosome 1. XCL1 induces it chemotactic function by binding to a chemokine receptor called XCR1.

ncbi gi num :

4506853

ncbi acc num :

NP_002986.1

ncbi gb acc num :

NM_002995.2

uniprot acc num :

P47992

ncbi mol weight :

12,517 Da

ncbi pathways :

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548)

ncbi summary :

This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]

uniprot summary :

XCL1: Chemotactic activity for lymphocytes but not for monocytes or neutrophils. Belongs to the intercrine gamma family. Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted. Chromosomal Location of Human Ortholog: 1q23. Cellular Component: extracellular space; extracellular region. Molecular Function: protein homodimerization activity; chemokine activity; chemokine receptor binding. Biological Process: neutrophil chemotaxis; negative regulation of T-helper 1 type immune response; positive regulation of T cell mediated cytotoxicity; response to virus; negative regulation of transcription factor activity; positive regulation of T cell cytokine production; positive regulation of leukocyte chemotaxis; negative regulation of T cell cytokine production; signal transduction; positive regulation of interleukin-10 production; negative regulation of interleukin-2 production; cell-cell signaling; negative regulation of interferon-gamma production; release of sequestered calcium ion into cytosol; regulation of inflammatory response; immune response; positive regulation of release of sequestered calcium ion into cytosol; negative regulation of transcription, DNA-dependent

size1 :

0.006 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage