protein

Recombinant Human I-309 (CCL1)

MBS142021

0.002 mg

140 USD

Recombinant Protein

Recombinant Human I-309 (CCL1)

I-309

I 309 Human; I-309 Human Recombinant (CCL1); Small inducible cytokine A1; CCL1; T lymphocyte-secreted protein I-309; chemokine (C-C motif) ligand 1; P500; SISe; TCA3; I-309; SCYA1

C-C motif chemokine 1; C-C motif chemokine 1; C-C motif chemokine 1; T lymphocyte-secreted protein I-309; inflammatory cytokine I-309; small inducible cytokine A1 (I-309, homologous to mouse Tca-3); chemokine (C-C motif) ligand 1; Small-inducible cytokine A1; T lymphocyte-secreted protein I-309

I 309

CCL1; CCL1; P500; SISe; TCA3; I-309; SCYA1; SCYA1

CCL1_HUMAN

E Coli

96

The sequence of the first five N-terminal amino acids was determined and was found to be Ser-Lys-Ser-Met-Gln.

Greater than 99.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The CCL1 protein was lyophilized with no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized I-309 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CCL1 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized I-309 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The Biological activity is calculated by its ability to chemoattract human T cells at 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

CHEMOKINES; Chemokines

Description: I-309 Human Recombinant produced in E Coli is a single,non-glycosylated, polypeptide chain containing 74 amino acids and having a molecular mass of 8504 Dalton. The I-309 is purified by proprietary chromatographic techniques. Introduction: Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family inflammatory cytokines known as chemokines. CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8. This chemokine resides in a large cluster of CC chemokines on human chromosome 17.

4506833

NP_002972.1

NM_002981.2

P22362

10,992 Da

Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460)

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine (C-C motif) receptor 8. [provided by RefSeq, Sep 2014]

CCL1: Cytokine that is chemotactic for monocytes but not for neutrophils. Binds to CCR8. Belongs to the intercrine beta (chemokine CC) family. Protein type: Chemokine; Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted. Chromosomal Location of Human Ortholog: 17q12. Cellular Component: extracellular space. Molecular Function: chemokine activity. Biological Process: cellular calcium ion homeostasis; viral reproduction; immune response; signal transduction; chemotaxis

0.002 mg

140 USD

0.01 mg

205

1 mg

2665