Recombinant Human GRO-gamma (CXCL3) | MyBioSource MBS142019 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human GRO-gamma (CXCL3)

catalog :

MBS142019

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142019

products type :

Recombinant Protein

products full name :

Recombinant Human GRO-gamma (CXCL3)

products short name :

GRO-gamma

products name syn :

GRO g Human; GRO-Gamma Human Recombinant (CXCL3); Macrophage inflammatory protein 2-beta; MIP2-beta; CXCL3; Growth-regulated protein gamma; GRO-gamma; GRO-gamma(1-73); GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b; MGSA gamma

other names :

C-X-C motif chemokine 3; C-X-C motif chemokine 3; C-X-C motif chemokine 3; GRO-gamma; GRO-gamma(1-73); GRO3 oncogene; MGSA gamma; MIP2-beta; growth-regulated protein gamma; macrophage inflammatory protein 2-beta; melanoma growth stimulatory activity gamma; chemokine (C-X-C motif) ligand 3; GRO-gamma(1-73); Growth-regulated protein gamma; GRO-gamma; Macrophage inflammatory protein 2-beta; MIP2-beta

products gene name :

GRO g

other gene names :

CXCL3; CXCL3; GRO3; GROg; MIP2B; SCYB3; MIP-2b; CINC-2b; GRO3; GROG; SCYB3; GRO-gamma; MIP2-beta

uniprot entry name :

CXCL3_HUMAN

host :

E Coli

sequence length :

107

sequence :

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Ser-Val-Val-Thr.

purity :

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The protein was lyophilized with no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized GRO-gamma although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CXCL3 should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized CXCL3 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The Biological activity is calculated by its ability to chemoattract CXCR2 transfected 293 cells using 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.

products categories :

CHEMOKINES; Chemokines; GRO

products description :

Description: GRO-Gamma Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 73 amino acids and having a molecular mass of 7902 Dalton. The CXCL3 is purified by proprietary chromatographic techniques. Introduction: Chemokine (C-X-C motif) ligand 3 (CXCL3) is a small cytokine belonging to the CXC chemokine family that is also known as GRO3 oncogene (GRO3), GRO protein gamma (GROg) and macrophage inflammatory protein-2-beta (MIP2b). CXCL3 controls migration and adhesion of monocytes and mediates it effects on its target cell by interacting with a cell surface chemokine receptor called CXCR2. The gene for CXCL3 is located on chromosome 4 in a cluster of other CXC chemokines.

ncbi gi num :

54144650

ncbi acc num :

NP_002081.2

ncbi gb acc num :

NM_002090.2

uniprot acc num :

P19876

ncbi mol weight :

11,342 Da

ncbi pathways :

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548)

ncbi summary :

This antimicrobial gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signals through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. [provided by RefSeq, Sep 2014]

uniprot summary :

CXCL3: Ligand for CXCR2. Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 4q21. Cellular Component: extracellular space; extracellular region. Molecular Function: chemokine activity; CXCR chemokine receptor binding. Biological Process: neutrophil chemotaxis; G-protein coupled receptor protein signaling pathway; immune response; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; inflammatory response; regulation of cell proliferation

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage