Recombinant Human Neutrophil Activating Protein-2 (CXCL7) | MyBioSource MBS142013 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Neutrophil Activating Protein-2 (CXCL7)

catalog :

MBS142013

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142013

products type :

Recombinant Protein

products full name :

Recombinant Human Neutrophil Activating Protein-2 (CXCL7)

products short name :

Neutrophil Activating Protein-2

products name syn :

NAP 2 Human; Neutrophil Activating Protein-2 Human Recombinant (CXCL7); Platelet basic protein; PBP; Small inducible cytokine B7; CXCL7; Leukocyte-derived growth factor; LDGF; Macrophage-derived growth factor; MDGF; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); TC1; TC2; TGB; TGB1; B-TG1; CTAP3; NAP-2; SCYB7; THBGB; LA-PF4; THBGB1; Beta-TG; CTAPIII; CTAP-III

other names :

platelet basic protein preproprotein; Platelet basic protein; platelet basic protein; C-X-C motif chemokine 7; CXC chemokine ligand 7; beta-thromboglobulin; connective tissue-activating peptide III; leukocyte-derived growth factor; low-affinity platelet factor IV; macrophage-derived growth factor; neutrophil-activating peptide 2; neutrophil-activating peptide-2; small inducible cytokine B7; small inducible cytokine subfamily B, member 7; small-inducible cytokine B7; thrombocidin 1; thrombocidin 2; thromboglobulin, beta-1; pro-platelet basic protein (chemokine (C-X-C motif) ligand 7); C-X-C motif chemokine 7; Leukocyte-derived growth factor; LDGF; Macrophage-derived growth factor; MDGF; Small-inducible cytokine B7Cleaved into the following 10 chains:Connective tissue-activating peptide III; CTAP-IIIAlternative name(s):LA-PF4; Low-affinity platelet factor IV

products gene name :

NAP 2

other gene names :

PPBP; PPBP; PBP; TC1; TC2; TGB; LDGF; MDGF; TGB1; B-TG1; CTAP3; CXCL7; NAP-2; SCYB7; THBGB; LA-PF4; THBGB1; Beta-TG; CTAPIII; CTAP-III; CTAP3; CXCL7; SCYB7; TGB1; THBGB1; PBP; LDGF; MDGF; CTAP-III; CTAP-III(1-81); Beta-TG; NAP-2(74); NAP-2(73); NAP-2; NAP-2(1-66); NAP-2(1-63)

uniprot entry name :

CXCL7_HUMAN

host :

E Coli

sequence length :

128

sequence :

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Glu-Leu-Arg-Cys.

purity :

Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The CXCL7 protein was lyophilized from a concentrated (1mg/ml) sterile solution containing no additives. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized NAP-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution CXCL7should be stored at 4 degree C between 2-7 days and for future use below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Neutrophil Activating Protein-2in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Biological Activity: The specific activity as determined by the ability of NAP2 to chemoattract human neurotrophils using a concentration of 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.

products categories :

CHEMOKINES; Chemokines; NAP-2 (CXCL7)

products description :

Description: Neutrophil Activating Protein-2 Human Recombinant produced in E Coli is a non-glycosylated, Polypeptide chain containing 70 amino acids and having a molecular mass of 7609 Dalton. The NAP-2 is purified by proprietary chromatographic techniques. Introduction: Chemokine (C-X-C motif) ligand (CXCL7) is a small cytokine belonging to the CXC chemokine family. It is a protein that is released in large amounts from platelets following their activation. It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator.

ncbi gi num :

4505981

ncbi acc num :

NP_002695.1

ncbi gb acc num :

NM_002704.3

uniprot acc num :

P02775

ncbi mol weight :

13,894 Da

ncbi pathways :

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548)

ncbi summary :

The protein encoded by this gene is a platelet-derived growth factor that belongs to the CXC chemokine family. This growth factor is a potent chemoattractant and activator of neutrophils. It has been shown to stimulate various cellular processes including DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by synovial cells. The protein also is an antimicrobial protein with bactericidal and antifungal activity. [provided by RefSeq, Nov 2014]

uniprot summary :

PPBP: LA-PF4 stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan. It also stimulates the formation and secretion of plasminogen activator by human synovial cells. NAP-2 is a ligand for CXCR1 and CXCR2, and NAP-2, NAP-2(73), NAP-2(74), NAP-2(1-66), and most potent NAP-2(1-63) are chemoattractants and activators for neutrophils. TC-1 and TC-2 are antibacterial proteins, in vitro released from activated platelet alpha-granules. CTAP-III(1-81) is more potent than CTAP-III desensitize chemokine-induced neutrophil activation. Belongs to the intercrine alpha (chemokine CxC) family. Protein type: Secreted, signal peptide; Chemokine; Secreted. Chromosomal Location of Human Ortholog: 4q12-q13. Cellular Component: extracellular space; extracellular region. Molecular Function: growth factor activity; chemokine activity; CXCR chemokine receptor binding; glucose transmembrane transporter activity. Biological Process: platelet activation; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; glucose transport; leukocyte migration during inflammatory response; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; platelet degranulation; positive regulation of cell division; defense response to bacterium; immune response; inflammatory response; blood coagulation

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage