Recombinant Mouse Parkinson Disease Protein 7 | MyBioSource MBS141169 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Mouse Parkinson Disease Protein 7

catalog :

MBS141169

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS141169

products type :

Recombinant Protein

products full name :

Recombinant Mouse Parkinson Disease Protein 7

products short name :

[Parkinson Disease Protein 7]

products name syn :

[PARK7 Mouse; Parkinson Disease Protein 7 Mouse Recombinant; Protein deglycase DJ-1; Parkinson disease protein 7 homolog]

other names :

[protein DJ-1; Protein deglycase DJ-1; protein deglycase DJ-1; Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7 homolog]

products gene name :

[PARK7]

products gene name syn :

[mPARK7]

other gene names :

[Park7; Park7; Dj1; DJ-1]

uniprot entry name :

PARK7_MOUSE

host :

E Coli

sequence length :

189

sequence :

MGSSHHHHHH SSGLVPRGSH MGS MASKRAL VILAKGAEEM ETVIPVDVMR RAGIKVTVAG LAGKDPVQCSRDVMICPDTS LEDAKTQGPY DVVVLPGGNL GAQNLSESPM VKEILKEQES RKGLIAAICA GPTALLAHEVGFGCKVTTHP LAKDKMMNGS HYSYSESRVE KDGLILTSRGPGTSFEFALA IVEALVGKDM ANQVKAPLVL KD

purity :

Greater than 90.0% as determined by SDS-PAGE.

form :

PARK7 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4), 20% glycerol and 1mM DTT. Sterile Filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS

products description :

Introduction: The PARK7 is a ubiquitously expressed protein involved in various cellular processes including spermatogenesis and fertilization, cancer, RNA-binding, androgen-receptor signaling and oxidative stress. Mutations in the PARK7 are the cause of autosomal recessive early-onset Parkinson's disease 7 (Park7). Description: PARK7 Mouse Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 212 amino acids (1-189 a.a) and having a molecular mass of 22.4kDa. PARK7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

ncbi gi num :

55741460

ncbi acc num :

NP_065594.2

ncbi gb acc num :

NM_020569.3

uniprot acc num :

Q99LX0

ncbi mol weight :

20,021 Da

ncbi pathways :

Parkinson's Disease Pathway (83295); MRNA Processing Pathway (198369)

uniprot summary :

DJ-1: associated with autosomal recessive early onset parkinsonism. Involved in the oxidative stress response. Three cysteines in DJ-1 may be oxidized to cysteine sulphonic acid in the cellular response to H2O2. Loss of DJ-1 function may lead to neurodegeneration. Protein type: EC 3.4.-.-; Nuclear receptor co-regulator; Transcription regulation; Tumor suppressor. Cellular Component: axon; cell-cell adherens junction; chromatin; cytoplasm; cytosol; endoplasmic reticulum; mitochondrial intermembrane space; mitochondrial matrix; mitochondrial respiratory chain complex I; mitochondrion; neuron projection; nucleus; perinuclear region of cytoplasm; PML body. Molecular Function: androgen receptor binding; copper ion binding; cytokine binding; enzyme binding; identical protein binding; kinase binding; mercury ion binding; mRNA binding; oxidoreductase activity, acting on peroxide as acceptor; peptidase activity; peroxiredoxin activity; protein binding; protein homodimerization activity; receptor binding; RNA binding; superoxide dismutase copper chaperone activity; transcription coactivator activity; transcription factor binding. Biological Process: adult locomotory behavior; cell proliferation; detoxification of copper ion; detoxification of mercury ion; dopamine uptake; enzyme active site formation via L-cysteine sulfinic acid; glycolate biosynthetic process; hydrogen peroxide metabolic process; lactate biosynthetic process; membrane depolarization; membrane hyperpolarization; methylglyoxal metabolic process; mitochondrion organization and biogenesis; negative regulation of apoptosis; negative regulation of neuron apoptosis; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of protein amino acid phosphorylation; negative regulation of protein binding; negative regulation of protein catabolic process; negative regulation of protein export from nucleus; negative regulation of protein kinase activity; negative regulation of protein sumoylation; negative regulation of protein ubiquitination; negative regulation of ubiquitin-protein ligase activity; positive regulation of interleukin-8 production; positive regulation of peptidyl-serine phosphorylation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; protein deglycosylation; protein stabilization; regulation of inflammatory response; regulation of mitochondrial membrane potential; regulation of neuron apoptosis; response to hydrogen peroxide; response to oxidative stress; synaptic transmission, dopaminergic

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage