Recombinant Human Guanine Nucleotide Binding Protein | MyBioSource MBS141135 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Guanine Nucleotide Binding Protein

catalog :

MBS141135

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS141135

products type :

Recombinant Protein

products full name :

Recombinant Human Guanine Nucleotide Binding Protein

products short name :

[Guanine Nucleotide Binding Protein]

products name syn :

[GNAQ Human; Guanine Nucleotide Binding Protein Human Recombinant; Guanine Nucleotide Binding Protein (G Protein); Q Polypeptide; Guanine Nucleotide-Binding Protein Alpha-Q; CMC1; SWS; GAQ; Guanine Nucleotide-Binding Protein G(Q) Subunit Alpha; G-ALPHA-Q; Guanine nucleotide-binding protein G(q) subunit alpha]

other names :

[guanine nucleotide-binding protein G(q) subunit alpha; Guanine nucleotide-binding protein G(q) subunit alpha; guanine nucleotide-binding protein G(q) subunit alpha; G protein subunit alpha q; Guanine nucleotide-binding protein alpha-q]

products gene name :

[GNAQ]

other gene names :

[GNAQ; GNAQ; GAQ; SWS; CMC1; G-ALPHA-q; GAQ]

uniprot entry name :

GNAQ_HUMAN

host :

E Coli

sequence length :

359

sequence :

MGSSHHHHHH SSGLVPRGSH MGS MTLESIM ACCLSEEAKE ARRINDEIER QLRRDKRDAR RELKLLLLGTGESGKSTFIK QMRIIHGSGY SDEDKRGFTK LVYQNIFTAM QAMIRAMDTL KIPYKYEHNK AHAQLVREVDVEKVSAFENP YVDAIKSLWN DPGIQECYDR RREYQLSDSTKYYLNDLDRV ADPAYLPTQQ DVLRVRVPTT GIIEYPFDLQ SVIFRMVDVGGQRSERRKWI HCFENVTSIM FLVALSEYDQ VLVESDNENR MEESKALFRT IITYPWFQNS SVILFLNKKDLLEEKIMYSH LVDYFPEYDG PQRDAQAARE FILKMFVDLN PDSDKIIYSH FTCATDTENIRFVFAAVKDT ILQLNLKEYN LV

purity :

Greater than 90.0% as determined by SDS-PAGE.

form :

GNAQ protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol

storage stability :

Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to ass a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

other info1 :

Physical Appearance: Sterile Filtered clear solution

products categories :

RECOMBINANT & NATURAL PROTEINS

products description :

Introduction: GNAQ, also known as Guanine nucleotide-binding protein belong to the G-alpha family. Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in a variety of transmembrane signaling systems. GNAQ regulates B-cell selection and survival and is essential in order to prevent B-cell-dependent autoimmunity. GNAQ also regulates chemotaxis of BM-derived neutrophils and dendritic cells, in vitro. GNAQ is an alpha subunit in the Gq class,. Description: GNAQ Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 382 amino acids (1-359 a.a) and having a molecular mass of 44.5kDa. GNAQ is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

ncbi gi num :

40254462

ncbi acc num :

NP_002063.2

ncbi gb acc num :

NM_002072.4

uniprot acc num :

P50148

ncbi mol weight :

42,142 Da

ncbi pathways :

ADP Signalling Through P2Y Purinoceptor 1 Pathway (1269354); Acetylcholine Regulates Insulin Secretion Pathway (1270104); Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Aldosterone Synthesis And Secretion Pathway (1272485); Aldosterone Synthesis And Secretion Pathway (1285075); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509)

uniprot summary :

G-alpha(q): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Protein type: G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q). Chromosomal Location of Human Ortholog: 9q21. Cellular Component: cytoplasm; lysosomal membrane; photoreceptor outer segment; plasma membrane. Molecular Function: GTPase activator activity; GTPase activity; protein binding; type 2A serotonin receptor binding. Biological Process: acetylcholine receptor signaling, muscarinic pathway; blood coagulation; dopamine receptor, phospholipase C activating pathway; entrainment of circadian clock; G-protein signaling, adenylate cyclase activating pathway; glutamate signaling pathway; negative regulation of protein kinase activity; phospholipase C activation; phototransduction, visible light; platelet activation; protein stabilization; regulation of action potential. Disease: Capillary Malformations, Congenital; Sturge-weber Syndrome

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage