product summary
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company name :
MyBioSource
product type :
antibody
product name :
Polyclonal Rabbit Anti Pancreas Duodenum Homeobox-1
catalog :
MBS141004
quantity :
0.01 ml
price :
140 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS141004
products type :
Antibody
products full name :
Polyclonal Rabbit Anti Pancreas Duodenum Homeobox-1
products short name :
Pancreas Duodenum Homeobox-1
products name syn :
PDX-1 antibody; Pancreas Duodenum Homeobox-1, Polyclonal Rabbit Antibody; IPF1; IUF1; IDX-1; MODY4; PDX1; STF-1; Insulin promoter factor 1; Pancreas Duodenum Homeobox-1
other names :
pancreas/duodenum homeobox protein 1; Pancreas/duodenum homeobox protein 1; pancreas/duodenum homeobox protein 1; IPF-1; IUF-1; glucose-sensitive factor; insulin promoter factor 1, homeodomain transcription factor; insulin upstream factor 1; islet/duodenum homeobox-1; pancreatic-duodenal homeobox factor 1; somatostatin transcription factor 1; somatostatin-transactivating factor 1; pancreatic and duodenal homeobox 1; Glucose-sensitive factor; GSF; Insulin promoter factor 1; IPF-1; Insulin upstream factor 1; IUF-1; Islet/duodenum homeobox-1; IDX-1; Somatostatin-transactivating factor 1; STF-1
products gene name :
PDX-1
other gene names :
PDX1; PDX1; GSF; IPF1; IUF1; IDX-1; MODY4; PDX-1; STF-1; PAGEN1; IPF1; STF1; PDX-1; GSF; IPF-1; IUF-1; IDX-1; STF-1
uniprot entry name :
PDX1_HUMAN
clonality :
Polyclonal
host :
Rabbit
sequence length :
283
specificity :
Human and Mouse PDX-1.
storage stability :
Stable for 2 yeas at -20 degree C. Avoid freeze/thaw cycles.
tested application :
Western Blot (WB), Immunohistochemistry (IHC)
app notes :
Western Blot: 1:1,000. Immunohistochemistry: 1:500. Optimal working dilutions must be determined by end user. Routinely evaluated by western blot on lysates of rat pancreatic cell line INS-1.
other info2 :
Immunogen: Recombinant PDX1 E Coli derived.
products categories :
MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Polyclonal Antibodies
products description :
Introduction: PDX1 activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. IPF1 is particularly involved in glucose-dependent regulation of insulin gene transcription. Pancreas Duodenum Homeobox-1 binds preferentially the DNA motif 5'-[ct]taat[tg]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, it is required for maintaining the hormone-producing phenotype of the beta-cell.
ncbi gi num :
4557673
ncbi acc num :
NP_000200.1
ncbi gb acc num :
NM_000209.3
ncbi mol weight :
35-40 kDa.
ncbi pathways :
Developmental Biology Pathway 477129!!FOXA2 And FOXA3 Transcription Factor Networks Pathway 137911!!Insulin Secretion Pathway 777534!!Maturity Onset Diabetes Of The Young Pathway 83096!!Maturity Onset Diabetes Of The Young Pathway 508!!Regulation Of Beta-cell Development Pathway 106328!!Regulation Of Gene Expression In Beta Cells Pathway 106332!!Regulation Of Gene Expression In Early Pancreatic Precursor Cells Pathway 106329!!Type II Diabetes Mellitus Pathway 83094!!Type II Diabetes Mellitus Pathway 198791
ncbi summary :
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008]
size :
0.01 ml
price :
140 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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