protein

Recombinant Human Cardiac Troponin-I, His Tag

MBS140908

0.1 mg

225 USD

Recombinant Protein

Recombinant Human Cardiac Troponin-I, His Tag

[Cardiac Troponin-I]

[TNNI3 Human, His; Cardiac Troponin-I Human Recombinant, His Tag; Troponin I cardiac muscle; Cardiac troponin I; TNNI3; TNNC1; CMH7; RCM1; cTnI; CMD2A; MGC116817]

[troponin I, cardiac muscle; Troponin I, cardiac muscle; troponin I, cardiac muscle; troponin I3, cardiac type; Cardiac troponin I]

[TNNI3]

[TNNI3; TNNI3; CMH7; RCM1; cTnI; CMD2A; TNNC1; CMD1FF; TNNC1]

TNNI3_HUMAN

E Coli

210

Protein is >95% pure as determined by 12% PAGE (coomassie staining).

TNNI3 protein solution (0.34 mg/mL) in PBS and 25 mM arginine.

TNNI3 although stable at 4°C for 1 week , should be stored below -18°C. Please prevent freeze thaw cycles.

Physical Appearance: Sterile Filtered Clear Solution.

RECOMBINANT & NATURAL PROTEINS

Introduction: Troponin I (TnI), troponin T (TnT) and troponin C (TnC) form the troponin complex of the thin filaments of striated muscle. TnI is acts as the inhibitory subunit by blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains 3 genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TNNI3 gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in the TNNI3 gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Description: Recombinant Human TNNI3 protein produced in E Coli is a full length protein containing a total of 260 amino acids and fused to a 6 His Tag at C-terminus, migrating as a 27kDa band on SDS-PAGE. Purified by proprietary chromatographic technique.

151101270

NP_000354.4

NM_000363.4

P19429

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Cardiac Progenitor Differentiation Pathway (712094); Cardiac Conduction Pathway (1339115); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591)

TNNI3: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Binds to actin and tropomyosin. Interacts with TRIM63. Interacts with STK4/MST1. Belongs to the troponin I family. Protein type: Actin-binding; Motility/polarity/chemotaxis; Motor. Chromosomal Location of Human Ortholog: 19q13.4. Cellular Component: cytosol; sarcomere; troponin complex. Molecular Function: actin binding; calcium channel inhibitor activity; calcium-dependent protein binding; protein binding; protein domain specific binding; protein kinase binding; troponin C binding; troponin T binding. Biological Process: cardiac muscle contraction; cellular calcium ion homeostasis; heart contraction; heart development; muscle filament sliding; negative regulation of ATPase activity; regulation of systemic arterial blood pressure by ischemic conditions; skeletal muscle contraction; vasculogenesis; ventricular cardiac muscle morphogenesis. Disease: Cardiomyopathy, Dilated, 1ff; Cardiomyopathy, Dilated, 2a; Cardiomyopathy, Familial Hypertrophic, 7; Cardiomyopathy, Familial Restrictive, 1

0.1 mg

225 USD

0.5 mg

645

1 mg

1220