protein

Recombinant Human Aspartylglucosaminidase

MBS140618

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Aspartylglucosaminidase

[Aspartylglucosaminidase]

[AGA Human; Aspartylglucosaminidase Human Recombinant; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; Aspartylglucosaminidase; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase; N (4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 1; AGU; ASRG; GA]

[N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 1 preproprotein; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase; aspartylglucosaminidase; Aspartylglucosaminidase; Glycosylasparaginase; N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase]

[AGA]

[AGA; AGA; GA; AGU; ASRG]

ASPG_HUMAN

346

MGSSHHHHHH SSGLVPRGSH MGS SSPLPLV VNTWPFKNAT EAAWRALASG GSALDAVESG CAMCEREQCD GSVGFGGSPD ELGETTLDAM IMDGTTMDVG AVGDLRRIKN AIGVARKVLE HTTHTLLVGE SATTFAQSMG FINEDLSTTA SQALHSDWLA RNCQPNYWRN VIPDPSKYCG PYKPPGILKQ DIPIHKETED DRGHDTIGMV VIHKTGHIAA GTSTNGIKFK IHGRVGDSPI PGAGAYADDT AGAAAATGNG DILMRFLPSY QAVEYMRRGE DPTIACQKVI SRIQKHFPEF FGAVICANVT GSYGAACNKL STFTQFSFMV YNSEKNQPTE EKVDCI.

Greater than 90% as determined by SDS-PAGE.

AGA protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0) and 10% glycerol.

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze/thaw cycles.

Source: E.coli. Physical Appearance: Sterile Filtered colorless solution.

ENZYMES

Introduction: Aspartylglucosaminidase, also known as AGA, takes part in the catabolism of Nlinked oligosaccharides of glycoproteins. AGA is a protein coding gene which cleaves asparagine from N-acetylglucosamines in the lysosomal breakdown of glycoproteins. Description: AGA Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 346 amino acids (24-346 a.a.) and having a molecular mass of 37kDa.AGA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

285002251

NP_000018.2

NM_000027.3

P20933

37,208 Da

Integrated Pancreatic Cancer Pathway (711360); L-asparagine Degradation III (mammalian) Pathway (1108791); Lysosome Pathway (99052); Lysosome Pathway (96865); Other Glycan Degradation Pathway (82976); Other Glycan Degradation Pathway (346); Asparagine Degradation Pathway (1108779)

AGA: a catabolic enzyme, aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme. Protein type: EC 3.5.1.26; Glycan Metabolism - other glycan degradation; Hydrolase. Chromosomal Location of Human Ortholog: 4q34.3. Cellular Component: endoplasmic reticulum; extracellular space; lysosome. Molecular Function: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity. Biological Process: protein deglycosylation. Disease: Aspartylglucosaminuria

0.005 mg

140 USD

0.02 mg

205

1 mg

2665