protein

Recombinant Human TIAL1

MBS140616

0.005 mg

140 USD

Recombinant Protein

Recombinant Human TIAL1

[TIAL1]

[TIAL1 Human; TIAL1 Human Recombinant; TCBP; TIAR; TIA1 cytotoxic granule-associated RNA binding protein-like 1; TIA-1-related protein]

[nucleolysin TIAR isoform 2; Nucleolysin TIAR; nucleolysin TIAR; TIA1 cytotoxic granule-associated RNA binding protein-like 1; TIA-1-related protein]

[TIAL1]

[TIAL1; TIAL1; TCBP; TIAR]

TIAR_HUMAN

392

MGSSHHHHHH SSGLVPRGSH MGSM MEDDGQ PRTLYVGNLS RDVTEVLILQ LFSQIGPCKS CKMITEHTSNDPYCFVEFYE HRDAAAALAA MNGRKILGKE VKVNWATTPS SQKKDTSNHF HVFVGDLSPE ITTEDIKSAFAPFGKISDAR VVKDMATGKS KGYGFVSFYN KLDAENAIVH MGGQWLGGRQ IRTNWATRKP PAPKSTQENNTKQLRFEDVV NQSSPKNCTV YCGGIASGLT DQLMRQTFSP FGQIMEIRVF PEKGYSFVRF STHESAAHAIVSVNGTTIEG HVVKCYWGKE SPDMTKNFQQ VDYSQWGQWS QVYGNPQQYG QYMANGWQVP PYGVYGQPWNQQGFGVDQSP SAAWMGGFGA QPPQGQAPPP VIPPPNQAGY GMASYQTQ

Greater than 90.0% as determined by SDS-PAGE.

TIAL1 protein solution (0.5mg/ml) containing Phosphate buffered saline (pH7.4), 50% glycerol, 2mM DTT and 1mM EDTA

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Source: E.Coli

Physical Appearance: Sterile Filtered clear solution.

RECOMBINANT & NATURAL PROTEINS

Introduction: TIAL1 belongs to a family of RNA-binding proteins, it has 3 RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a extensive range of genes. TIAL1 regulates a variety of activities including translational control, splicing and apoptosis. TIAL1 different isoforms function differently with respect to post-transcriptional silencing. Description: TIAL1 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 398 amino acids (1-375 a.a) and having a molecular mass of 44.0kDa.TIAL1 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

77695912

NP_001029097.1

NM_001033925.1

Q01085

TIAL1: a member of a family of RNA-binding proteins that possesses nucleolytic activity. A cytotoxic T cell granule-associated protein that has been shown to bind specifically to poly(A) homopolymers and to fragment DNA in permeabilized target cells. Members of this protein family may be involved in the induction of apoptosis. Two splice variant isoforms have been described. Protein type: Apoptosis; RNA-binding. Chromosomal Location of Human Ortholog: 10q. Cellular Component: cytoplasm; lysosome; nucleoplasm; nucleus; stress granule. Molecular Function: RNA binding. Biological Process: defense response; fibroblast growth factor receptor signaling pathway; regulation of transcription from RNA polymerase II promoter

0.005 mg

140 USD

0.02 mg

205

1 mg

2665