protein

Recombinant Human Delta-Like 1

MBS140611

0.002 mg

140 USD

Recombinant Protein

Recombinant Human Delta-Like 1

[Delta-Like 1 ]

[DLK1, Delta-Like 1 Homolog (Drosophila), PREF1, DLK-1, FA1, DLK, PG2, Delta-Like Homolog (Drosophila), Protein Delta Homolog 1, Preadipocyte Factor 1, Fetal Antigen 1, Secredeltin, DELTA1, Pref-1, ZOG]

[protein delta homolog 1 isoform 2 preproprotein; Protein delta homolog 1; protein delta homolog 1; delta-like 1 homolog (Drosophila); pG2]

[DLK1]

[DLK1; DLK1; DLK; FA1; ZOG; pG2; DLK-1; PREF1; Delta1; Pref-1; DLK; DLK-1; FA1]

DLK1_HUMAN

310

AECFPACNPQ NGFCEDDNVC RCQPGWQGPL CDQCVTSPGC LHGLCGEPGQ CICTDGWDGE LCDRDVRACS SAPCANNGTC VSLDDGLYEC SCAPGYSGKD CQKKDGPCVI NGSPCQHGGT CVDDEGRASH ASCLCPPGFS GNFCEIVANS CTPNPCENDG VCTDIGGDFR CRCPAGFIDK TCSRPVTNCA SSPCQNGGTC LQHTQVSYEC LCKPEFTGLT CVKKRALSPQ QVTRLPSGYG LAYRLTPGVH ELPVQQPEHR ILKVSMKELN KKTPLLTEGQ LEHHHHHH.

Greater than 95.0% as determined by SDS-PAGE.

Appearance:Sterile filtered colorless clear solution. DLK1 protein solution (0.25mg/ml) containing Phosphate Buffered Saline(pH7.4) and 10% glycerol.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Source: Sf9 Baculovirus Cells.

RECOMBINANT & NATURAL PROTEINS

Introduction: Delta-Like 1, also known as DLK1 is a member of the Notch/Delta/Serrate family of epidermal growth factor (EGF)-like repeat-containing proteins which act as ligands in the Notch signaling pathway. Furthermore, DLK1 has six highly conserved epidermal-growth-factor motifs and it also contains up to ten O-glycosylation and N-glycosylation locations, six of them are differentially glycosylated. Description: DLK1 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 288 amino acids (24-303 a.a) and having a molecular mass of 30.7kDa (Migrates at 28-40kDa on SDS-PAGE under reducing conditions). DLK1 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

953514558

NP_001304101.1

NM_001317172.1

P80370

33,067 Da

Activated NOTCH1 Transmits Signal To The Nucleus Pathway (1269536); Adipogenesis Pathway (198832); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Notch Signaling Pathway (169345); Signal Transduction Pathway (1269379); Signaling By NOTCH Pathway (1269530); Signaling By NOTCH1 Pathway (1269535)

DLK1: May have a role in neuroendocrine differentiation. Monomer. Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 14q32. Cellular Component: extracellular space. Biological Process: negative regulation of Notch signaling pathway

0.002 mg

140 USD

0.01 mg

205

1 mg

5015