Mouse Anti Human Tubulin beta-2B chain | MyBioSource MBS140371 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti Human Tubulin beta-2B chain

catalog :

MBS140371

quantity :

0.005 mg

price :

140 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PAT5B2AT

reactivity :

human

application :

western blot, ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS140371

products type :

Antibody

products full name :

Mouse Anti Human Tubulin beta-2B chain

products short name :

Tubulin beta-2B chain

products name syn :

TUBB2B Antibody; Tubulin beta-2B chain, Mouse Anti Human; Tubulin beta-2B chain; TUBB2B; MGC8685; FLJ98847; bA506K6.1; DKFZp566F223; RP11-506K6.1

other names :

tubulin beta-2B chain; Tubulin beta-2B chain; tubulin beta-2B chain; class II beta-tubulin isotype; class IIb beta-tubulin; tubulin, beta polypeptide paralog; tubulin, beta 2B class IIb

products gene name :

TUBB2b

other gene names :

TUBB2B; TUBB2B; PMGYSA; bA506K6.1

uniprot entry name :

TBB2B_HUMAN

clonality :

Monoclonal

isotype :

IgG2a heavy chain and k light chain

clone :

PAT5B2AT

host :

Mouse

sequence length :

445

purity :

TUBB2b antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

form :

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide. Sterile Filtered clear solution.

storage stability :

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.

tested application :

ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

app notes :

TUBB2b antibody has been tested by ELISA, Western blot and Immunofluorescence analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis and Immunofluorescence is 1:250 ~ 500. Recommended starting dilution is 1:250.

other info2 :

Immunogen: Anti-human TUBB2b mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TUBB2b amino acids 1-445 purified from E Coli.

products categories :

MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies

products description :

Introduction: TUBB2B is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. Numerous beta Tubulin isoforms have been characterized and are expressed in mammalian tissues. Tubulin binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB2b is mostly expressed in developing neurons with a dominant expression during the critical steps of corticogenesis. In addition, TUBB2B is a new critical gene involved in neuronal migration. TUBB2B is present in the nuclei and nucleoplasm, Defects in the TUBB2B gene are a cause of asymmetric polymicrogyria.

ncbi gi num :

29788768

ncbi acc num :

NP_821080.1

ncbi gb acc num :

NM_178012.4

ncbi mol weight :

49,953 Da

ncbi pathways :

Chaperonin-mediated Protein Folding Pathway (106242); Cooperation Of Prefoldin And TriC/CCT In Actin And Tubulin Folding Pathway (106243); Formation Of Tubulin Folding Intermediates By CCT/TriC Pathway (106245); Gap Junction Pathway (83072); Gap Junction Pathway (483); Metabolism Of Proteins Pathway (106230); Orphan Transporters Pathway (1127546); Parkin-Ubiquitin Proteasomal System Pathway (700638); Pathogenic Escherichia Coli Infection Pathway (83103); Pathogenic Escherichia Coli Infection Pathway (672459)

ncbi summary :

The protein encoded by this gene is a beta isoform of tubulin, which binds GTP and is a major component of microtubules. This gene is highly similar to TUBB2A and TUBB2C. Defects in this gene are a cause of asymmetric polymicrogyria. [provided by RefSeq, Mar 2010]

uniprot summary :

TUBB2B: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain. TUBB2B is implicated in neuronal migration. Defects in TUBB2B are a cause of polymicrogyria asymmetric (PMGA). PMGA is a malformation of the cortex in which the brain surface is irregular and characterized by an excessive number of small gyri with abnormal lamination. Belongs to the tubulin family. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 6p25. Cellular Component: microtubule; cytoplasm; nucleus. Molecular Function: GTPase activity; protein binding; GTP binding; structural constituent of cytoskeleton. Biological Process: protein polymerization; de novo posttranslational protein folding; cellular protein metabolic process; protein folding; neuron migration; transmembrane transport; microtubule-based process. Disease: Polymicrogyria, Symmetric Or Asymmetric

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

0.1 mg

price3 :

505

more info or order :

MyBioSource product webpage