Mouse Anti Human Aurora Kinase B | MyBioSource MBS140364 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti Human Aurora Kinase B

catalog :

MBS140364

quantity :

0.02 mg

price :

205 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

PAT2B1AT

reactivity :

human

application :

ELISA, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS140364

products type :

Antibody

products full name :

Mouse Anti Human Aurora Kinase B

products short name :

Aurora Kinase B

products name syn :

AURKB Antibody; Aurora Kinase B, Mouse Anti Human; Serine/threonine-protein kinase 12; Aurora kinase B; Serine/threonine-protein kinase aurora-B; Aurora- and Ipl1-like midbody-associated protein 1; Aurora/IPL1-related kinase 2; Aurora-related kinase 2; AIM-1; ARK-2; STK-1; AURKB; AIK2; AIM1; ARK2; STK12; AurB; IPL1; STK5; aurkb-sv1; aurkb-sv2

other names :

aurora kinase B isoform 1; Aurora kinase B; aurora kinase B; ARK-2; STK-1; aurora 1; aurora kinase B-Sv1; aurora kinase B-Sv2; aurora- and Ipl1-like midbody-associated protein 1; aurora-1; aurora-B; aurora-related kinase 2; aurora/IPL1-related kinase 2; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; serine/threonine-protein kinase 12; serine/threonine-protein kinase 5; serine/threonine-protein kinase aurora-B; aurora kinase B; Aurora 1; Aurora- and IPL1-like midbody-associated protein 1; AIM-1; Aurora/IPL1-related kinase 2; ARK-2; Aurora-related kinase 2; STK-1; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B

products gene name :

AURKB

other gene names :

AURKB; AURKB; AIK2; AIM1; ARK2; AurB; IPL1; STK5; AIM-1; STK12; PPP1R48; aurkb-sv1; aurkb-sv2; AIK2; AIM1; AIRK2; ARK2; STK1; STK12; STK5; AIM-1; ARK-2; Aurora-related kinase 2

uniprot entry name :

AURKB_HUMAN

clonality :

Monoclonal

isotype :

IgG2b heavy chain and kappa light chain

clone :

PAT2B1AT

host :

Mouse

sequence length :

344

purity :

AURKB antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

form :

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

storage stability :

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.

tested application :

ELISA (EIA), Immunofluorescence (IF)

app notes :

AURKB antibody has been tested by ELISA and Immunofluorescence analyses to assure specificity and reactivity. Since applications vary, each investigation should be titrated by a reagent to obtain optimal results. Recommended dilution range for Immunofluorescence is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.

other info2 :

Immunogen: Anti-human AURKB mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human AURKB amino acids 1-344 purified from E Coli.

products categories :

MONOCLONAL ANTIBODIES, ANTI-HUMAN ENZYMES; Monoclonal Antibodies; Anti Human Enzyme

products description :

Introduction: Aurora Kinase B (AURKB) belongs to a family of mitotic serine/threonine kinases. AURKB connects with chromosomes for the period of prophase prior to relocalizing to the spindle at anaphase. AURKB localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. AURKB controls chromosome segregation through the control of microtubule-kinetochore attachment and cytokinesis. AURKB is required for kinetochore localization of BUB1 and SGOL1. AURKB expression during the G2/M phase transition is firmly coordinated with histone H3 phosphorylation, while overexpression is seen in many kinds of cancers. AURKB phosphorylates ''Ser-10'' and ''Ser-28'' of histone H3 during mitosis. AURKB is a component of the CPC (chromosomal passenger complex), which is a complex that acts as a key regulator of mitosis. High level expression of AURKB is seen in the thymus, which is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. AURKB is expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.

ncbi gi num :

83776600

ncbi acc num :

NP_004208.2

ncbi gb acc num :

NM_004217.3

ncbi mol weight :

39,467 Da

ncbi pathways :

APC/C-mediated Degradation Of Cell Cycle Proteins Pathway 105825!!APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway 105835!!Aurora A Signaling Pathway 137925!!Aurora B Signaling Pathway 138080!!Aurora C Signaling Pathway 138003!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!FOXM1 Transcription Factor Network Pathway 137935!!M Phase Pathway 105812!!Mitotic Anaphase Pathway 105818

ncbi summary :

This gene encodes a member of the aurora kinase subfamily of serine/threonine kinases. The genes encoding the other two members of this subfamily are located on chromosomes 19 and 20. These kinases participate in the regulation of segregation of chromosomes during mitosis and meiosis through association with microtubules. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]

size :

0.02 mg

price :

205 USD

more info or order :

MyBioSource product webpage