antibody

Mouse Anti Human Nicotinamide Nucleotide Adenylyltransferase 1

MBS140351

0.02 mg

205 USD

monoclonal

mouse

nonconjugated

PAT4A2AT

western blot, ELISA, enzyme immunoassay

Antibody

Mouse Anti Human Nicotinamide Nucleotide Adenylyltransferase 1

Nicotinamide Nucleotide Adenylyltransferase 1

NMNAT1 Antibody; Nicotinamide Nucleotide Adenylyltransferase 1, Mouse Anti Human; NMNAT; NMNAT1; PNAT1; Nicotinamide mononucleotide adenylyltransferase 1; NMN adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltransferase 1; EC=2.7.7.1; EC=2.7.7.18

nicotinamide mononucleotide adenylyltransferase 1 isoform 1; Nicotinamide mononucleotide adenylyltransferase 1; nicotinamide mononucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NaMN adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 1; pyridine nucleotide adenylyltransferase 1; nicotinamide nucleotide adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1 (EC:2.7.7.18); NaMN adenylyltransferase 1

NMNAT1

NMNAT1; NMNAT1; LCA9; NMNAT; PNAT1; NMNAT; NMN adenylyltransferase 1; NaMN adenylyltransferase 1

NMNA1_HUMAN

Monoclonal

IgG2b heavy chain and kappa light chain

PAT4A2AT

Mouse

279

NMNAT1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.

ELISA (EIA), Western Blot (WB)

NMNAT1 antibody has been tested by ELISA and Western blot analyses to assure specificity and reactivity. Since applications vary, each investigation should be titrated by a reagent to obtain optimal results. Recommended dilution range for Western blot is 1:500 ~ 1000.Recommended starting dilution is 1:500.

Immunogen: Anti-human NMNAT1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human NMNAT1 amino acids 1-279 purified from E Coli.

MONOCLONAL ANTIBODIES, ANTI-HUMAN ENZYMES; Monoclonal Antibodies; Anti Human Enzyme

Introduction: NMNAT1 enzyme is vital for NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD. NMNAT1 is widely expressed with high levels in skeletal muscle, heart, liver and kidney. This protein appears to have the ability to protect against axonal degeneration following mechanical or toxic insults.

20070321

NP_073624.2

NM_022787.3

31,932 Da

Defective AMN Causes Hereditary Megaloblastic Anemia 1 Pathway 906000!!Defective BTD Causes Biotidinase Deficiency Pathway 906015!!Defective CD320 Causes Methylmalonic Aciduria Pathway 906012!!Defective CUBN Causes Hereditary Megaloblastic Anemia 1 Pathway 906001!!Defective GIF Causes Intrinsic Factor Deficiency Pathway 906004!!Defective HLCS Causes Multiple Carboxylase Deficiency Pathway 906014!!Defective LMBRD1 Causes Methylmalonic Aciduria And Homocystinuria Type CblF Pathway 906003!!Defective MMAA Causes Methylmalonic Aciduria Type CblA Pathway 906010!!Defective MMAB Causes Methylmalonic Aciduria Type CblB Pathway 906009!!Defective MMACHC Causes Methylmalonic Aciduria And Homocystinuria Type CblC Pathway 906005

This gene encodes an enzyme which catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). The encoded enzyme is one of several nicotinamide nucleotide adenylyltransferases, and is specifically localized to the cell nucleus. Activity of this protein leads to the activation of a nuclear deacetylase that functions in the protection of damaged neurons. Mutations in this gene have been associated with Leber congenital amaurosis 9. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14, and 15. [provided by RefSeq, Jul 2014]

0.02 mg

205 USD