catalog number :
MBS140345
products full name :
Mouse Anti Human Lymphotoxin-alpha
products short name :
Lymphotoxin-alpha
products name syn :
LTA Antibody; Lymphotoxin-alpha, Mouse Anti Human; Lymphotoxin-alpha; LT-alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1; LTA; TNFB; TNFSF1; LT
other names :
LTA protein (Lymphotoxin alpha) (TNF superfamily, member 1); LTA protein; LTA protein
uniprot entry name :
Q6FG55_HUMAN
isotype :
IgG2b heavy chain
purity :
LTA antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
form :
1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide. Sterile Filtered clear solution.
storage stability :
For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.
tested application :
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
app notes :
LTA antibody has been tested by ELISA, Western blot and Immunofluorescence analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis and Immunofluorescence is 1:250 ~ 500.Recommended starting dilution is 1:250.
other info2 :
Immunogen: Anti-human LTA mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human LTA amino acids 35-205 purified from E Coli.
products categories :
ANTI-HUMAN CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine
products description :
Introduction: Lymphotoxin-alpha (LT-alpha or LTA) belongs to the TNF ligand superfamily, which bind the same TNF receptor and mediate similar pleiotropic effect. LTA is a proinflammatory cytokine with important biological activity and immunomodulatory function and is known to influence a variety of cellular response. Furthermore, LTA mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and has a role in apoptosis. LTA is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchors lymphotoxin-alpha to the cell surface. LTA, which is located within the MHC III region of chromosome 6, shows close relation to the HLA class I (HLA-B) and class II (HLA-DR) genes. Polymorphism in the LTA gene appears to contribute to infectious disease susceptibility and infection. Genetic variations in the LTA gene are linked to susceptibility to leprosy type 4 and psoriatic arthritis.
ncbi mol weight :
22,350 Da