Mouse Anti Human Triggering receptor expressed on myeloid cells 2 | MyBioSource MBS140325 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti Human Triggering receptor expressed on myeloid cells 2

catalog :

MBS140325

quantity :

0.005 mg

price :

140 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

P2B5AT

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS140325

products type :

Antibody

products full name :

Mouse Anti Human Triggering receptor expressed on myeloid cells 2

products short name :

Triggering receptor expressed on myeloid cells 2

products name syn :

TREM2 Antibody; Triggering receptor expressed on myeloid cells 2, Mouse Anti Human; Triggering receptor expressed on myeloid cells 2; Triggering receptor expressed on monocytes 2; TREM-2; TREM2; Trem2a; Trem2b; Trem2c

other names :

triggering receptor expressed on myeloid cells 2 isoform 1; Triggering receptor expressed on myeloid cells 2; triggering receptor expressed on myeloid cells 2; triggering receptor expressed on monocytes 2; triggering receptor expressed on myeloid cells 2a; triggering receptor expressed on myeloid cells 2; Triggering receptor expressed on monocytes 2

products gene name :

TREM2

other gene names :

TREM2; TREM2; TREM-2; Trem2a; Trem2b; Trem2c; TREM-2

uniprot entry name :

TREM2_HUMAN

clonality :

Monoclonal

isotype :

IgG3 heavy chain and kappa light chain

clone :

P2B5AT

host :

Mouse

sequence length :

230

purity :

TREM2 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

form :

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

concentration :

1mg/ml

storage stability :

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

TREM2 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000.Recommended starting dilution is 1:500.

other info2 :

Immunogen: Anti-human TREM2 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TREM2 amino acids 19-161 purified from E Coli.

products categories :

MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies

products description :

Introduction: TREM2 is a membrane protein that forms a receptor signaling complex with TYROBP. TREM2 may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in the TREM2 gene are a source of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL).

ncbi gi num :

9507203

ncbi acc num :

NP_061838.1

ncbi gb acc num :

NM_018965.3

ncbi mol weight :

24,669 Da

ncbi pathways :

Axon Guidance Pathway (105688); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550); Developmental Biology Pathway (477129); Immune System Pathway (106386); Innate Immune System Pathway (106387); Osteoclast Differentiation Pathway (193147); Osteoclast Differentiation Pathway (193096); Other Semaphorin Interactions Pathway (119526); Semaphorin Interactions Pathway (119519)

ncbi summary :

This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

uniprot summary :

TREM2: May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. Defects in TREM2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); also known as presenile dementia with bone cysts or Nasu-Hakola disease (NHD). PLOSL is a recessively inherited disease characterized by a combination of psychotic symptoms rapidly progressing to presenile dementia and bone cysts restricted to wrists and ankles. PLOSL has a global distribution, although most of the patients have been diagnosed in Finland and Japan, with an estimated population prevalence of 2x10(-6) in the Finns. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral. Chromosomal Location of Human Ortholog: 6p21.1. Cellular Component: intracellular membrane-bound organelle; extracellular region; plasma membrane; integral to membrane. Molecular Function: peptidoglycan binding; lipopolysaccharide binding; receptor activity. Biological Process: axon guidance; positive regulation of peptidyl-tyrosine phosphorylation; detection of lipopolysaccharide; detection of peptidoglycan; innate immune response; positive regulation of calcium-mediated signaling; humoral immune response; positive regulation of antigen processing and presentation of peptide antigen via MHC class II. Disease: Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

0.1 mg

price3 :

505

more info or order :

MyBioSource product webpage