Mouse Anti Human Transforming Growth Factor Beta Induced | MyBioSource MBS140323 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti Human Transforming Growth Factor Beta Induced

catalog :

MBS140323

quantity :

0.005 mg

price :

140 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Pk1H12AT

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS140323

products type :

Antibody

products full name :

Mouse Anti Human Transforming Growth Factor Beta Induced

products short name :

Transforming Growth Factor Beta Induced

products name syn :

TGFBI Antibody; Transforming Growth Factor Beta Induced, Mouse Anti Human; Transforming growth factor-beta-induced protein ig-h3; Beta ig-h3; Kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP; TGFBI; BIGH3; CSD; CDB1; CDG2; CSD1; CSD2; CSD3; EBMD; LCD1; CDGG1

other names :

transforming growth factor-beta-induced protein ig-h3; Transforming growth factor-beta-induced protein ig-h3; transforming growth factor-beta-induced protein ig-h3; RGD-CAP; RGD-containing collagen-associated protein; beta ig-h3; kerato-epithelin; transforming growth factor, beta-induced, 68kD; transforming growth factor, beta-induced, 68kDa; Kerato-epithelin; RGD-containing collagen-associated protein; RGD-CAP

products gene name :

TGFBI

other gene names :

TGFBI; TGFBI; CSD; CDB1; CDG2; CSD1; CSD2; CSD3; EBMD; LCD1; BIGH3; CDGG1; BIGH3; Beta ig-h3; RGD-CAP

uniprot entry name :

BGH3_HUMAN

clonality :

Monoclonal

isotype :

IgG2a heavy chain and kappa light chain

clone :

Pk1H12AT

host :

Mouse

sequence length :

683

purity :

TGFBI antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

form :

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

storage stability :

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

TGFBI antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000.

other info2 :

Immunogen: Anti-human TGFBI mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human TGFBI amino acids 502-636 purified from E Coli.

products categories :

MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies

products description :

Introduction: Transforming Growth Factor Beta Induced protein also known as TGFBI is an extracellular matrix protein induced by transforming growth factor (TGF)-beta 1. TGFBI protein is involved in cell growth, cell differentiation, wound healing and cell adhesion. In addition, some missense mutations of TGFBI were identified in families affected with human autosomal dominant corneal dystrophies. TGFBI gene encodes for a 683 amino-acid protein containing an RGD motif and four internal repeated domains which have highly conserved sequences founded in several species (Fasciclin domain).

ncbi gi num :

4507467

ncbi acc num :

NP_000349.1

ncbi gb acc num :

NM_000358.2

ncbi mol weight :

74,681 Da

ncbi pathways :

Amyloids Pathway (366238); Disease Pathway (530764)

ncbi summary :

This gene encodes an RGD-containing protein that binds to type I, II and IV collagens. The RGD motif is found in many extracellular matrix proteins modulating cell adhesion and serves as a ligand recognition sequence for several integrins. This protein plays a role in cell-collagen interactions and may be involved in endochondrial bone formation in cartilage. The protein is induced by transforming growth factor-beta and acts to inhibit cell adhesion. Mutations in this gene are associated with multiple types of corneal dystrophy. [provided by RefSeq, Jul 2008]

uniprot summary :

betaIG-H3: Binds to type I, II, and IV collagens. This adhesion protein may play an important role in cell-collagen interactions. In cartilage, may be involved in endochondral bone formation. By TGFB1. Highly expressed in the corneal epithelium. Protein type: Extracellular matrix; Secreted; Secreted, signal peptide; Cell adhesion. Chromosomal Location of Human Ortholog: 5q31. Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region; plasma membrane; basement membrane; trans-Golgi network. Molecular Function: collagen binding; integrin binding; protein binding; extracellular matrix binding. Biological Process: cell proliferation; extracellular matrix organization and biogenesis; visual perception; response to stimulus; chondrocyte differentiation; angiogenesis; negative regulation of cell adhesion; cell adhesion. Disease: Corneal Dystrophy, Epithelial Basement Membrane; Corneal Dystrophy, Lattice Type Iiia; Corneal Dystrophy Of Bowman Layer, Type Ii; Corneal Dystrophy, Avellino Type; Corneal Dystrophy, Lattice Type I; Corneal Dystrophy Of Bowman Layer, Type I; Corneal Dystrophy, Groenouw Type I

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

0.1 mg

price3 :

505

more info or order :

MyBioSource product webpage