catalog number :
MBS1403139
products type :
Recombinant Protein
products full name :
Recombinant Mouse Group XV phospholipase A2 (Pla2g15)
products short name :
[Group XV phospholipase A2 (Pla2g15)]
other names :
[group XV phospholipase A2 isoform 1; Group XV phospholipase A2; group XV phospholipase A2; phospholipase A2, group XV; 1-O-acylceramide synthase]
products gene name :
[Pla2g15]
products gene name syn :
[Pla2g15]
other gene names :
[Pla2g15; Pla2g15; ACS; LLPL; Lpla2; C87498; Lypla3; Lypla3; LPLA2]
host :
E Coli or Yeast or Baculovirus or Mammalian Cell
sequence positions :
[34-412aa; Full Length of Mature Protein]
sequence :
AQRHPPVVLVPGDLGNQLEAKLDKPKVVHYLCSKKTDSY
FTLWLNLELLLPVIIDCWIDNIRLVYNRTSRATQFPDGV
DVRVPGFGETFSMEFLDPSKRNVGSYFYTMVESLVGWGY
TRGEDVRGAPYDWRRAPNENGPYFLALREMIEEMYQMYG
GPVVLVAHSMGNVYMLYFLQRQPQVWKDKYIHAFVSLGA
PWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTS
WLLPYNHTWSHEKVFVYTPTTNYTLRDYHRFFRDIGFED
GWFMRQDTEGLVEAMTPPGVELHCLYGTGVPTPNSFYYE
SFPDRDPKICFGDGDGTVNLESVLQCQAWQSRQEHRVSL
QELPGSEHIEMLANATTLAYLKRVLLEP
purity :
Greater than 85% as determined by SDS-PAGE.
form :
Liquid containing glycerol
storage stability :
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
other info1 :
Species: Mus musculus (Mouse)
other info2 :
Storage Buffer: Tris-based buffer, 50% glycerol. Production Note: Special Offer: The E Coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E Colihost-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E Coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E Coli host-expressed protein for the fastest delivery among all hosts. Please contact our technical support team or email to support@mybiosource.com for more details.
products categories :
Epigenetics and Nuclear Signaling
products description :
Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid. Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine. Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen
products references :
The measurement of lysosomal phospholipase A2 activity in plasma." Abe A., Kelly R., Shayman J.A. J. Lipid Res. 51:2464-2470(2010)
ncbi acc num :
NP_598553.1
ncbi gb acc num :
NM_133792.3
ncbi mol weight :
50.5 kDa
ncbi pathways :
Glycerophospholipid Metabolism Pathway (83188); Glycerophospholipid Metabolism Pathway (364); Lysosome Pathway (99272); Lysosome Pathway (96865)
uniprot summary :
Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (PubMed:11790796, PubMed:16106046, PubMed:16880524, PubMed:19017977, PubMed:20410020). Has high activity with 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), catalyzing the transfer of oleic acid to N-acetyl-sphingosine (PubMed:16880524). Required for normal phospholipid degradation in alveolar and peritoneal macrophages and in spleen (PubMed:16880524, PubMed:19017977).