antibody

Mouse Anti Human Interleukin-33

MBS140278

0.02 mg

205 USD

monoclonal

mouse

nonconjugated

P4E9AT

western blot, ELISA, enzyme immunoassay

Antibody

Mouse Anti Human Interleukin-33

Interleukin-33

IL33 Antibody; Interleukin-33, Mouse Anti Human; Interleukin 33; DVS27; NF-HEV; NKHEV; C9orf26; Interleukin-1 family member 11; IL- 1F11; Nuclear factor from high endothelial venules; NFEHEV; DKFZp586H0523; RP11-575C20.2; IL-33

interleukin-33 isoform 2; Interleukin-33; interleukin-33; DVS27-related protein; IL-1F11; IL-33; interleukin-1 family member 11; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules; interleukin 33; Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules; NF-HEV

IL33

IL33; IL33; DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV

IL33_HUMAN

Monoclonal

IgG2b heavy chain and kappa light chain

P4E9AT

Mouse

228

IL33 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide. Sterile Filtered colorless solution.

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.

ELISA (EIA), Western Blot (WB)

IL33 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.

Immunogen: Anti-human IL33 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human IL33 amino acids 112-270 purified from E Coli.

ANTI-HUMAN CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine

Introduction: Interleukin 33 (IL-33) is a 32kDa proinflammatory cytokine that may also regulate gene transcription in producer cells. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1 (IL1 receptor-like-1), which is known also as ST2. Binding of IL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces expression of IL-4, IL-5, IL-13 and leads to severe pathological changes in mucosal organs and in vitro, it can be divided to N-terminal fragment of 12kDa and C-terminal fragment of 18kDa by cleavage of caspase-1.

313851030

NP_001186569.1

NM_001199640.1

16,250 Da

Cytosolic DNA-sensing Pathway 125137!!Cytosolic DNA-sensing Pathway 124833!!Influenza A Pathway 217173!!Influenza A Pathway 217150

IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]

0.02 mg

205 USD