antibody

Mouse Anti Human Heat shock protein HSP 90-alpha

MBS140261

0.005 mg

140 USD

monoclonal

mouse

nonconjugated

P4F10AT

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Mouse Anti Human Heat shock protein HSP 90-alpha

Heat shock protein HSP 90-alpha

HSP90 Alpha Antibody; Heat shock protein HSP 90-alpha, Mouse Anti Human; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; HSP90A; HSP90N; HSPCAL1; HSPCAL4; FLJ31884; Heat shock protein HSP 90-alpha; Renal carcinoma antigen NY-REN-38; HSP 86; HSP90AA1

heat shock protein HSP 90-alpha isoform 1; Heat shock protein HSP 90-alpha; heat shock protein HSP 90-alpha; HSP 86; LPS-associated protein 2; epididymis luminal secretory protein 52; heat shock 86 kDa; heat shock 90kD protein 1, alpha; heat shock 90kD protein 1, alpha-like 4; heat shock 90kD protein, alpha-like 4; heat shock 90kDa protein 1, alpha; lipopolysaccharide-associated protein 2; renal carcinoma antigen NY-REN-38; heat shock protein 90kDa alpha (cytosolic), class A member 1; Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38

HSP90 Alpaha

HSP90AA1; HSP90AA1; EL52; HSPN; LAP2; HSP86; HSPC1; HSPCA; Hsp89; Hsp90; LAP-2; HSP89A; HSP90A; HSP90N; HSPCAL1; HSPCAL4; HSP90A; HSPC1; HSPCA; HSP 86; HSP86; LAP-2; LPS-associated protein 2

HS90A_HUMAN

Monoclonal

IgG2b heavy chain and kappa light chain

P4F10AT

Mouse

854

HSP90A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide. Sterile Filtered clear solution.

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

HSP90A antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot is 1:500 ~ 1:2,000 and immunohistochemistry analysis is 1:100~200. Recommended starting dilution for Western blot is 1:1,000 and Immunohistochemistry is 1:100.

Immunogen: Anti-human HSP90A mAb, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HSP90A amino acids 1-732 purified from E Coli.

MONOCLONAL ANTIBODIES, ANTI-HUMAN HEAT SHOCK PROTEINS; Monoclonal Antibodies; Anti Human Heat Shock Protein

Introduction: HSP90 has been identified in the cytosol, nucleus and endoplasmic reticulum, and is reported to exist in many tissue types. In several tissues, including smooth muscle, HSP90 comprises up to 2% of total cellular protein. HSP90 functions as a dimer, assembled as part of heterocomplex. It possesses ATP-binding site and low ATPase activity. HSP90 is able to associate with actin filaments in certain conditions. Another important property of HSP90 is the binding of unoccupied steroid hormone receptors. HSP90 has been characterized as a molecular chaperone able to keep the target protein in a folding-competent state. It has an enhanced chaperone activity in oligomeric form at high temperatures. HSP90 function is sensitive to bivalent cations concentration.

153792590

NP_001017963.2

NM_001017963.2

98,161 Da

AhR Pathway (755436); Anchoring Of The Basal Body To The Plasma Membrane Pathway (1127503); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Assembly Of The Primary Cilium Pathway (1127502); Attenuation Phase Pathway (1127556); Axon Guidance Pathway (105688); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Cell Cycle Pathway (530733); Cell Cycle, Mitotic Pathway (105765)

The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

HSP90A: a molecular chaperone of the heat shock protein 90 family. Has ATPase activity. Known to interact with a wide variety of proteins including steroid hormone receptors, neuropeptide Y, FKBP51/54, and FKBP52. G protein-coupled receptor kinases are stabilized by interacting with HSP 90. Hsp70 and Hsp90 promote tau solubility and tau binding to microtubules, reducing insoluble tau phosphorylation of tau. Protein type: Chaperone; Heat shock protein. Chromosomal Location of Human Ortholog: 14q32.33. Cellular Component: nucleoplasm; mitochondrion; membrane; cytoplasm; plasma membrane; extracellular region; melanosome; nucleus; cytosol. Molecular Function: identical protein binding; protein binding; protein homodimerization activity; TPR domain binding; unfolded protein binding; ATPase activity; nitric-oxide synthase regulator activity; nucleotide binding; ATP binding. Biological Process: receptor-mediated endocytosis; axon guidance; positive regulation of nitric oxide biosynthetic process; organelle organization and biogenesis; signal transduction; nitric oxide metabolic process; protein import into mitochondrial outer membrane; response to unfolded protein; mitochondrial transport; innate immune response; protein refolding; regulation of nitric-oxide synthase activity; mitotic cell cycle; vascular endothelial growth factor receptor signaling pathway; chaperone-mediated protein complex assembly; G2/M transition of mitotic cell cycle

0.005 mg

140 USD

0.02 mg

205

0.1 mg

505