antibody

Mouse Anti Human HCLS1-associated protein X-1

MBS140257

0.02 mg

205 USD

monoclonal

mouse

nonconjugated

PAT3C5AT

western blot, ELISA, enzyme immunoassay

Antibody

Mouse Anti Human HCLS1-associated protein X-1

HCLS1-associated protein X-1

HAX1 Antibody; HCLS1-associated protein X-1, Mouse Anti Human; HCLS1-associated protein X-1; HS1-associating protein X-1; HS1-binding protein 1; HAX-1; HSP1BP-1; HAX1; HS1BP1

HCLS1-associated protein X-1 isoform b; HCLS1-associated protein X-1; HCLS1-associated protein X-1; HAX-1; HCLS1 (and PKD2) associated protein; HS1 binding protein; HS1-associating protein X-1; HS1-binding protein 1; HSP1BP-1; HCLS1 associated protein X-1; HS1-associating protein X-1; HAX-1; HS1-binding protein 1; HSP1BP-1

HAX1

HAX1; HAX1; SCN3; HS1BP1; HCLSBP1; HS1BP1; HAX-1; HSP1BP-1

HAX1_HUMAN

Monoclonal

IgG2b heavy chain and kappa light chain

PAT3C5AT

Mouse

231

HAX1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.

ELISA (EIA), Western Blot (WB)

HAX1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.

Immunogen: Anti-human HAX1 mAb is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HAX1 amino acids 1-279 purified from E Coli.

MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies

Introduction: HAX1 associates with hematopoietic cell-specific Lyn substrate 1, which is a substrate of Src family tyrosine kinases. HAX1 also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought HAX1 is mainly localized to the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in the HAX1 gene result in autosomal recessive severe congenital neutropenia, aka Kostmann disease.

66363694

NP_001018238.1

NM_001018837.1

21,801 Da

The protein encoded by this gene is known to associate with hematopoietic cell-specific Lyn substrate 1, a substrate of Src family tyrosine kinases. It also interacts with the product of the polycystic kidney disease 2 gene, mutations in which are associated with autosomal-dominant polycystic kidney disease, and with the F-actin-binding protein, cortactin. It was earlier thought that this gene product is mainly localized in the mitochondria, however, recent studies indicate it to be localized in the cell body. Mutations in this gene result in autosomal recessive severe congenital neutropenia, also known as Kostmann disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

0.02 mg

205 USD