antibody

Mouse Anti Human Cysteine-Rich Angiogenic Inducer 61

MBS140242

0.005 mg

140 USD

monoclonal

mouse

nonconjugated

P3H3AT

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Mouse Anti Human Cysteine-Rich Angiogenic Inducer 61

Cysteine-Rich Angiogenic Inducer 61

CYR61 Antibody; Cysteine-Rich Angiogenic Inducer 61, Mouse Anti Human; CYR61; Protein CYR61; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IGF-binding protein 10; IGFBP-10; IBP-10; Protein GIG1; CCN family member 1; CCN1; GIG1; IGFBP10

protein CYR61; Protein CYR61; protein CYR61; CCN family member 1; IBP-10; IGF-binding protein 10; IGFBP-10; cysteine-rich heparin-binding protein 61; cysteine-rich, anigogenic inducer, 61; insulin-like growth factor-binding protein 10; cysteine-rich, angiogenic inducer, 61; CCN family member 1; Cysteine-rich angiogenic inducer 61; Insulin-like growth factor-binding protein 10; IBP-10; IGF-binding protein 10; IGFBP-10; Protein GIG1

CYR61

CYR61; CYR61; CCN1; GIG1; IGFBP10; CCN1; GIG1; IGFBP10; IBP-10; IGF-binding protein 10; IGFBP-10

CYR61_HUMAN

Monoclonal

IgG1 heavy chain and kappa light chain

P3H3AT

Mouse

381

CYR61 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide. Sterile Filtered clear solution.

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

CYR61 antibody has been tested by ELISA, Western blot and immunohistochemistry analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot is 1:250~1:1,000 and immunohistochemistry analysis is 1:50~100. Recommended starting dilution for Western blot is 1:250 and Immunohistochemistry is 1:50.

Immunogen: Anti-human CYR61 mAb, is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CYR61 amino acids 168-242 purified from E Coli.

ANTI-HUMAN CYTOKINES; Monoclonal Antibodies; Anti Human Cytokine

Introduction: CYR61 is a growth factor-inducible, immediate-early gene that has multifaceted activities in various cancers. CYR61 is a secreted, cysteine-rich, heparin-binding protein which is encoded by a growth factor-inducible immediate-early gene. Acting as an extracellular, matrix-associated signaling molecule, CYR61 promotes the adhesion of endothelial cells through interaction with integrin and enhances growth factor-induced DNA synthesis in the same cell type.

31542331

NP_001545.2

NM_001554.4

42,027 Da

Hypertrophy Model Pathway (198828); Oncostatin M Signaling Pathway (711361); Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway (169352); RhoA Signaling Pathway (169356); Amb2 Integrin Signaling Pathway (137945)

The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]

CYR61: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up- regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CYR61-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. Belongs to the CCN family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1p22.3. Cellular Component: extracellular matrix; proteinaceous extracellular matrix. Molecular Function: integrin binding; heparin binding; insulin-like growth factor binding; extracellular matrix binding. Biological Process: anatomical structure morphogenesis; extracellular matrix organization and biogenesis; positive regulation of caspase activity; chemotaxis; intussusceptive angiogenesis; osteoblast differentiation; positive regulation of osteoblast differentiation; cell proliferation; cell-cell signaling; positive regulation of protein kinase activity; positive regulation of osteoblast proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; regulation of cell growth; cell adhesion; positive regulation of BMP signaling pathway; negative regulation of apoptosis; positive regulation of cell migration

0.005 mg

140 USD

0.02 mg

205

0.1 mg

505