Mouse Anti Human C-C chemokine receptor type 6 | MyBioSource MBS140226 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti Human C-C chemokine receptor type 6

catalog :

MBS140226

quantity :

0.005 mg

price :

140 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

P4C6AT

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS140226

products type :

Antibody

products full name :

Mouse Anti Human C-C chemokine receptor type 6

products short name :

C-C chemokine receptor type 6

products name syn :

CCR6 Antibody; C-C chemokine receptor type 6, Mouse Anti Human; C-C chemokine receptor type 6; LARC receptor; GPR-CY4; Chemokine receptor-like 3; DRY6; G-protein coupled receptor 29; CD196; C-C CKR-6; CC-CKR-6; CCR-6; GPRCY4; CKR-L3; CCR6; CKRL3; CMKBR6; GPR29; STRL22; BN-1; CKR6; DCR2; DRY-6; GPRCY4; GPR-CY4

other names :

C-C chemokine receptor type 6; C-C chemokine receptor type 6; C-C chemokine receptor type 6; G protein-coupled receptor 29; G-protein coupled receptor 29; LARC receptor; chemokine (C-C) receptor 6; chemokine receptor-like 3; seven-transmembrane receptor, lymphocyte, 22; chemokine (C-C motif) receptor 6; Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; GPR-CY4; GPRCY4; LARC receptor; CD_antigen: CD196

products gene name :

CCR6

other gene names :

CCR6; CCR6; BN-1; DCR2; DRY6; CCR-6; CD196; CKRL3; GPR29; CKR-L3; CMKBR6; GPRCY4; STRL22; CC-CKR-6; C-C CKR-6; CKRL3; CMKBR6; GPR29; STRL22; C-C CKR-6; CC-CKR-6; CCR-6; CKR-L3; GPRCY4

uniprot entry name :

CCR6_HUMAN

clonality :

Monoclonal

isotype :

IgG1 heavy chain and kappa light chain

clone :

P4C6AT

host :

Mouse

sequence length :

374

purity :

CCR6 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

form :

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

storage stability :

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

CCR6 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.

other info2 :

Immunogen: Anti-human CCR6 mAb, is derived from hybridization of mouse F0myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CCR6 amino acids 1-46 purified from E Coli.

products categories :

MONOCLONAL ANTIBODIES, ANTI-HUMAN CHEMOKINES; Monoclonal Antibodies; Anti Human Chemokine

products description :

Introduction: CCR6 belongs to the beta chemokine receptor family, which is predicted to be a 7 transmembrane protein similar to G protein-coupled receptors. CCR6 is preferentially expressed by immature dendritic cells and memory T cells. The ligand of CCR6 receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). CCR6 receptor has been shown to be vital for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses.

ncbi gi num :

37187860

ncbi acc num :

NP_004358.2

ncbi gb acc num :

NM_004367.5

ncbi mol weight :

42,494 Da

ncbi pathways :

Beta Defensins Pathway (530759); Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Defensins Pathway (530757); Disease Pathway (530764)

ncbi summary :

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

uniprot summary :

CCR6: Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, integral; GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 6q27. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; dendritic cell chemotaxis; cellular defense response; innate immune response; immune response; cell motility; chemotaxis; signal transduction; humoral immune response

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

0.1 mg

price3 :

505

more info or order :

MyBioSource product webpage