catalog number :
MBS140221
products full name :
Mouse Anti Human Casein kinase I isoform alpha
products short name :
Casein kinase I isoform alpha
products name syn :
CSNK1A1 Antibody; Casein kinase I isoform alpha, Mouse Anti Human; Casein kinase I isoform alpha; CKI-alpha; CK1; CSNK1A1; HLCDGP1; PRO2975
other names :
casein kinase I isoform alpha isoform 1; Casein kinase I isoform alpha; casein kinase I isoform alpha; CKI-alpha; clock regulator kinase; down-regulated in lung cancer; epididymis secretory sperm binding protein Li 77p; casein kinase 1, alpha 1; CK1
products gene name :
CSNK1A1
other gene names :
CSNK1A1; CSNK1A1; CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p; CKI-alpha
uniprot entry name :
KC1A_HUMAN
isotype :
IgG2b heavy chain and kappa light chain
purity :
CSNK1A1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
form :
1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
storage stability :
For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
CSNK1A1 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1000 ~ 2000. Recommended starting dilution is 1:1000.
other info2 :
Immunogen: Anti-human CSNK1A1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CSNK1A1 amino acids 1-337 purified from E Coli.
products categories :
MONOCLONAL ANTIBODIES, ANTI-HUMAN ENZYMES; Monoclonal Antibodies; Anti Human Enzyme
products description :
Introduction: Caseine Kinase 1 alpha belongs is a member of the protein kinase superfamily, CK1 Ser/Thr protein kinase family, Casein kinase I subfamily. The CK1 isoforms - alpha, beta, gamma, delta, epsilon and their splice variants are involved in diverse cellular processes including membrane trafficking, circadian rhythm, cell cycle progression, chromosome segregation, apoptosis and cellular differentiation. Possibly CSNK1A1 can phosphorylate a large number of proteins and is involved in Wnt signaling where it phosphorylates CTNNB1 on Ser45. CSNK1A1 also interacts with the Axin complex.
ncbi acc num :
NP_001020276.1
ncbi gb acc num :
NM_001025105.2
ncbi mol weight :
37,567 Da
ncbi pathways :
AMER1 Mutants Destabilize The Destruction Complex Pathway 1127621!!APC Truncation Mutants Are Not K63 Polyubiquitinated Pathway 1127616!!APC Truncation Mutants Have Impaired AXIN Binding Pathway 1127617!!AXIN Missense Mutants Destabilize The Destruction Complex Pathway 1127620!!AXIN Mutants Destabilize The Destruction Complex, Activating WNT Signaling Pathway 1127618!!Activation Of SMO Pathway 1127544!!Beta-catenin Phosphorylation Cascade Pathway 106512!!Canonical Wnt Signaling Pathway 138032!!Degradation Of GLI2 By The Proteasome Pathway 1127540!!Degradation Of Beta-catenin By The Destruction Complex Pathway 106511