antibody

Mouse Anti Human Amyloid Beta A4 Protein

MBS140213

0.02 mg

205 USD

monoclonal

mouse

nonconjugated

PJ4H9AT

western blot, ELISA, enzyme immunoassay

Antibody

Mouse Anti Human Amyloid Beta A4 Protein

Amyloid Beta A4

APP Antibody; Amyloid Beta A4 Protein, Mouse Anti Human; Amyloid beta A4 protein; Alzheimer disease amyloid protein; ABPP; APPI; APP; PreA4; Cerebral vascular amyloid peptide; CVAP; Protease nexin-II; PN-II; A4; AD1; AAA; PN2; ABETA; CTFgamma

amyloid beta A4 protein isoform a; Amyloid beta A4 protein; amyloid beta A4 protein; alzheimer disease amyloid protein; beta-amyloid peptide; beta-amyloid peptide(1-40); beta-amyloid peptide(1-42); cerebral vascular amyloid peptide; peptidase nexin-II; preA4; protease nexin-II; amyloid beta (A4) precursor protein; ABPP; APPI; APP; Alzheimer disease amyloid protein; Cerebral vascular amyloid peptide; CVAP; PreA4; Protease nexin-II; PN-II

APP

APP; APP; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma; A4; AD1; APP; CVAP; PN-II; S-APP-alpha; S-APP-beta; AICD-59; AID(59); AICD-57; AID(57); AICD-50; AID(50)

A4_HUMAN

Monoclonal

IgG2b heavy chain and kappa light chain

PJ4H9AT

Mouse

770

APP antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.

ELISA (EIA), Western Blot (WB)

APP antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:1,000 ~ 2,000. Recommended starting dilution is 1:1,000.

Immunogen: Anti-human APP mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human APP amino acids 18-289 purified from E Coli.

MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies

Introduction: APP is a cell surface receptor and transmembrane precursor protein which is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in the APP gene are implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy).

4502167

NP_000475.1

NM_000484.3

84,521 Da

Activated TLR4 Signalling Pathway 106400!!Advanced Glycosylation Endproduct Receptor Signaling Pathway 187092!!Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Amyloids Pathway 366238!!Caspase Cascade In Apoptosis Pathway 137974!!Class A/1 (Rhodopsin-like Receptors) Pathway 106357!!Cytosolic Sensors Of Pathogen-associated DNA Pathway 576255!!DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway 833822

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

0.02 mg

205 USD