Mouse Anti Human Activation-induced cytidine deaminase | MyBioSource MBS140210 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti Human Activation-induced cytidine deaminase

catalog :

MBS140210

quantity :

0.005 mg

price :

140 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

P2D3AT

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS140210

products type :

Antibody

products full name :

Mouse Anti Human Activation-induced cytidine deaminase

products short name :

Activation-induced cytidine deaminase

products name syn :

AICDA Antibody; Activation-induced cytidine deaminase, Mouse Anti Human; Activation-induced cytidine deaminase; Cytidine aminohydrolase; AICDA; AID; ARP2; CDA2; HIGM2

other names :

single-stranded DNA cytosine deaminase; Single-stranded DNA cytosine deaminase; single-stranded DNA cytosine deaminase; cytidine aminohydrolase; epididymis secretory protein Li 284; integrated into Burkitt's lymphoma cell line Ramos; activation-induced cytidine deaminase; Activation-induced cytidine deaminase; Cytidine aminohydrolase

products gene name :

AICDA

other gene names :

AICDA; AICDA; AID; ARP2; CDA2; HIGM2; HEL-S-284; AID

uniprot entry name :

AICDA_HUMAN

clonality :

Monoclonal

isotype :

IgG1 heavy chain and kappa light chain

clone :

P2D3AT

host :

Mouse

sequence length :

198

purity :

AICDA antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

form :

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.

storage stability :

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

AICDA antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1,000. Recommended starting dilution is 1:500.

other info2 :

Immunogen: Anti-human AICDA mAb, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human AICDA amino acids 1-54 purified from E Coli.

products categories :

MONOCLONAL ANTIBODIES, ANTI-HUMAN ENZYMES; Monoclonal Antibodies; Anti Human Enzyme

products description :

Introduction: AICDA is an RNA-editing deaminase which belongs to the cytidine deaminase family. AICDA is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in the AICDA gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2).

ncbi gi num :

10190700

ncbi acc num :

NP_065712.1

ncbi gb acc num :

NM_020661.2

ncbi mol weight :

22,614 Da

ncbi pathways :

IL4-mediated Signaling Events Pathway (137933); Intestinal Immune Network For IgA Production Pathway (128760); Intestinal Immune Network For IgA Production Pathway (128670); Primary Immunodeficiency Pathway (83125); Primary Immunodeficiency Pathway (537)

ncbi summary :

This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009]

uniprot summary :

AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family. Protein type: Hydrolase; EC 3.5.4.38. Chromosomal Location of Human Ortholog: 12p13. Cellular Component: cytoplasm; exosome (RNase complex); nucleus. Molecular Function: protein binding; zinc ion binding; ubiquitin protein ligase binding; cytidine deaminase activity. Biological Process: somatic diversification of immunoglobulins; B cell differentiation; somatic hypermutation of immunoglobulin genes; isotype switching; cytidine deamination; mRNA processing. Disease: Immunodeficiency With Hyper-igm, Type 2

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

0.1 mg

price3 :

505

more info or order :

MyBioSource product webpage