catalog number :
MBS140197
products full name :
Mouse Anti Human HTRA2
products short name :
HTRA2
products name syn :
HTRA2 Antibody; HTRA2, Mouse Anti Human; Serine protease HTRA2 mitochondrial; EC 3.4.21.108; High temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; Serine proteinase OMI; Serine protease 25; OMI; PARK13; PRSS25
other names :
HtrA2, isoform B; Serine protease HTRA2, mitochondrial; CG8464 gene product from transcript CG8464-RB; CG8464-PA; CG8464-PB; HtrA2; HtrA2-PA; HtrA2-PB; High temperature requirement protein A2; Omi stress-regulated endoprotease; ;
products gene name :
HTRA2
other gene names :
HtrA2; HtrA2; CG8464; DmelCG8464; DmHtrA2; domi; dOmi; htrA2; htrA2/omi; HtrA2/Omi; omi; Omi
uniprot entry name :
HTRA2_DROME
isotype :
IgG1 heavy chain and kappa light chain
purity :
HTRA2 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
form :
1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
storage stability :
For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
HTRA2 antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 2,000. Recommended starting dilution is 1:1,000.
other info2 :
Immunogen: Anti-human HTRA2 mAb is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HTRA2 amino acids 134-458 purified from E Coli.
products categories :
MONOCLONAL ANTIBODIES, ANTI-HUMAN ENZYMES; Monoclonal Antibodies; Anti Human Enzyme
products description :
Introduction: HtrA2 also called Omi is a mammalian serine protease at high temperatures and has a chaperone activity at low temperature. The full-length HtrA2 is synthesized as a precursor protein and then targeted to the mitochondria where it is matured by the removal of N-terminal 133 residues. Mature HtrA2 consists of a putative transmembrane domain; an inhibitor of apoptosis protein (IAP)-binding motif; a single C-terminal PDZ domain that mediates protein-protein interactions. Recently, HtrA2 has known to contribute both to caspase-dependent and caspase-independent cell death.
ncbi acc num :
NP_001262565.1
ncbi gb acc num :
NM_001275636.1
ncbi mol weight :
46,000 Da