Mouse Anti Human Cathepsin D | MyBioSource MBS140196 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Mouse Anti Human Cathepsin D

catalog :

MBS140196

quantity :

0.005 mg

price :

140 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

P4G2AT

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS140196

products type :

Antibody

products full name :

Mouse Anti Human Cathepsin D

products short name :

Cathepsin D

products name syn :

CTSD Antibody; Cathepsin D, Mouse Anti Human; Cathepsin D; EC 3.4.23.5; CTSD; CPSD; CLN10; MGC2311

other names :

cathepsin D preproprotein; Cathepsin D; cathepsin D; ceroid-lipofuscinosis, neuronal 10; epididymis secretory sperm binding protein Li 130P; lysosomal aspartyl peptidase; lysosomal aspartyl protease; cathepsin D

products gene name :

CTSD

other gene names :

CTSD; CTSD; CPSD; CLN10; HEL-S-130P; CPSD

uniprot entry name :

CATD_HUMAN

clonality :

Monoclonal

isotype :

IgG2b heavy chain and kappa light chain

clone :

P4G2AT

host :

Mouse

sequence length :

412

purity :

CTSD antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.

form :

1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide. Sterile Filtered colorless solution.

storage stability :

For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles. 12 months at -20 degree C. 1 month at 4 degree C.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

CTSD antibody has been tested by ELISA and Western blot analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 2,000. Recommended starting dilution is 1:1,000.

other info2 :

Immunogen: Anti-human CTSD mAb is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CTSD amino acids 21-412 purified from E Coli.

products categories :

MONOCLONAL ANTIBODIES, ANTI-HUMAN ENZYMES; Monoclonal Antibodies; Anti Human Enzyme

products description :

Introduction: Cathepsin D is synthesized as a 54kDa precursor, which is proteolytically processed to an intermediate 48kDa single chain, which matures into more stable 34kDa and 14kDa two chain form. It is an estrogen-regulated lysosomal protease that has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix, and xonnective tissue. Because of its mitogenic and proteolytic activities, it has been implicated as a prognostic marker in many tumor types. Cathepsin D is expressed in epithelial cells as well as in macrophages.

ncbi gi num :

4503143

ncbi acc num :

NP_001900.1

ncbi gb acc num :

NM_001909.4

ncbi mol weight :

44,552 Da

ncbi pathways :

Adaptive Immune System Pathway (366160); Ceramide Signaling Pathway (138023); Collagen Degradation Pathway (730309); Degradation Of The Extracellular Matrix Pathway (576263); Direct P53 Effectors Pathway (137939); Extracellular Matrix Organization Pathway (576262); Immune System Pathway (106386); LKB1 Signaling Events Pathway (137957); Lysosome Pathway (99052); Lysosome Pathway (96865)

ncbi summary :

This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008]

uniprot summary :

CTSD: Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. Consists of a light chain and a heavy chain. Belongs to the peptidase A1 family. Protein type: Autophagy; Protease; EC 3.4.23.5; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: extracellular matrix; extracellular space; lysosomal lumen; lysosome; melanosome; extracellular region. Molecular Function: protein binding; aspartic-type endopeptidase activity. Biological Process: collagen catabolic process; extracellular matrix disassembly; extracellular matrix organization and biogenesis; antigen processing and presentation of exogenous peptide antigen via MHC class II; proteolysis. Disease: Ceroid Lipofuscinosis, Neuronal, 10

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

0.1 mg

price3 :

505

more info or order :

MyBioSource product webpage