catalog number :
MBS140186
products full name :
MHC Class II, Mouse Anti Human
products short name :
[MHC Class II]
products name syn :
[MHC Class II Antibody; MHC Class II, Mouse Anti-Human]
other names :
[MHC class II HLA-DQ-beta-1; MHC class II HLA-DQ-beta-1; MHC class II HLA-DQ-beta-1]
products gene name :
[MHC Class II]
other gene names :
[HLA-DQB1]
uniprot entry name :
O19707_HUMAN
specificity :
All haplotypes.
purity :
Ion exchange column.
concentration :
1mg/ml in PBS (after reconstitution).
storage stability :
Lyophilized: store at 4 degree C. After reconstitution, if not intended for use within a month, aliquot and store at -20 degree C. Antibody is shipped lyophilized at ambient temperature. Shipping Condition: Antibody is shipped lyophilized at ambient temperature.
tested application :
Flow Cytometry (FC/FACS), Western Blot (WB), Immunoprecipitation (IP)
app notes :
FACS staining, Western Blot, Immunoprecipitation. Staining antibody. For staining, use 10 ul/1,000,000 cells.
other info1 :
Physical Appearance: Sterile filtered white lyophilized (freeze-dried) powder.
other info2 :
Reconstitution: Reconstitute with of H2O mix gently, wash the sides of the vial and wait 30-60 seconds before use. Titer: Staining anitbody. For staining, use 10ul/10^6 cells. Immunogen: Purified Human B cells. Available Conjugates: This antibody is currently available only as purified antibody.
products categories :
MONOCLONAL/POLYCLONAL ANTIBODIES, MISCELLANEOUS ANTIBODIES; Monoclonal Antibodies
products description :
Introduction: MHC Class II is consists of 2 membrane spanning proteins. Each of these proteins is roughly 30 kDa, and has of two Globular domains, Alpha-1, Alpha-2, Beta-1 and Beta-2. The two regions farthest away from the membrane are alpha-1 and beta-1. The two proteins link without Covalent Bonds. The MHC Class II protein mainly presents peptides, which have been digested from external sources. MHC Class II is normally only expressed by Antigen Presenting Cells (APC) which digest foreign protein. Within the RER the alpha and beta proteins of the molecule, associate with each other, while a third protein called the "invariant chain," is necessary for stabilizing the complex, without it, they will not associate. The MHC-invariant complex is then passed from the RER, into and out of, the Golgi body. It fuses with an Endocytic compartment, where an external protein has been sampled and degraded.
ncbi mol weight :
26,489 Da